Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity
and mortality: A pooled analysis
#MMPMID32738466
Henry BM
; Aggarwal G
; Wong J
; Benoit S
; Vikse J
; Plebani M
; Lippi G
Am J Emerg Med
2020[Sep]; 38
(9
): 1722-1726
PMID32738466
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Coronavirus disease 2019 (COVID-19) infection has now reached a pandemic state,
affecting more than a million patients worldwide. Predictors of disease outcomes
in these patients need to be urgently assessed to decrease morbidity and societal
burden. Lactate dehydrogenase (LDH) has been associated with worse outcomes in
patients with viral infections. In this pooled analysis of 9 published studies
(n = 1532 COVID-19 patients), we evaluated the association between elevated LDH
levels measured at earliest time point in hospitalization and disease outcomes in
patients with COVID-19. Elevated LDH levels were associated with a ~6-fold
increase in odds of developing severe disease and a ~16-fold increase in odds of
mortality in patients with COVID-19. Larger studies are needed to confirm these
findings.
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