Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection: let the
virus be its own demise
#MMPMIDC7249572
Nemunaitis J
; Stanbery L
; Senzer N
Future Virol
2020[Apr]; ? (?): ? PMIDC7249572
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There has been a collaborative global effort to construct novel therapeutic and
prophylactic approaches to SARS-CoV-2 management. Although vaccine development is
crucial, acute management of newly infected patients, especially those with
severe acute respiratory distress syndrome, is a priority. Herein we describe the
rationale and potential of repurposing a dual plasmid, Vigil
(pbi-shRNA(furin)-GM-CSF), now in Phase III cancer trials, for the treatment of
and, in certain circumstances, enhancement of the immune response to SARS-CoV-2.