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10.1016/j.vaccine.2020.05.064 http://scihub22266oqcxt.onion/10.1016/j.vaccine.2020.05.064 C7247514!7247514 !32507409     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32507409 &cmd=llinks): Failed to open stream: HTTP request failed! 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Consensus summary report for CEPI/BC March 12-13, 2020 meeting: Assessment of risk of disease enhancement with COVID-19 vaccines |pdf=|usr=}}{{32507409 }} gab.com Text Consensus summary report for CEPI/BC March 12-13, 2020 meeting: Assessment of risk of disease enhancement with COVID-19 vaccines JO: Vaccine http://www.kidney.de/pget.php?&tw=1&pmid=32507409 #FOAvip A novel coronavirus (CoV), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in late 2019 in Wuhan, China and has since spread as a global pandemic. Safe and effective vaccines are thus urgently needed to reduce the significant morbidity and mortality of Coronavirus Disease 2019 (COVID-19) disease and ease the major economic impact. There has been an unprecedented rapid response by vaccine developers with now over one hundred vaccine candidates in development and at least six having reached clinical trials. However, a major challenge during rapid development is to avoid safety issues both by thoughtful vaccine design and by thorough evaluation in a timely manner. A syndrome of "disease enhancement" has been reported in the past for a few viral vaccines where those immunized suffered increased severity or death when they later encountered the virus or were found to have an increased frequency of infection. Animal models allowed scientists to determine the underlying mechanism for the former in the case of Respiratory syncytial virus (RSV) vaccine and have been utilized to design and screen new RSV vaccine candidates. Because some Middle East respiratory syndrome (MERS) and SARS-CoV-1 vaccines have shown evidence of disease enhancement in some animal models, this is a particular concern for SARS-CoV-2 vaccines. To address this challenge, the Coalition for Epidemic Preparedness Innovations (CEPI) and the Brighton Collaboration (BC) Safety Platform for Emergency vACcines (SPEAC) convened a scientific working meeting on March 12 and 13, 2020 of experts in the field of vaccine immunology and coronaviruses to consider what vaccine designs could reduce safety concerns and how animal models and immunological assessments in early clinical trials can help to assess the risk. This report summarizes the evidence presented and provides considerations for safety assessment of COVID-19 vaccine candidates in accelerated vaccine development. Twit Text FOAVip Consensus summary report for CEPI/BC March 12-13, 2020 meeting: Assessment of risk of disease enhancement with COVID-19 vaccines ????Vaccine http://www.kidney.de/pget.php?&tw=1&pmid=32507409 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32507409 #FOAvip English Wikipedia <ref>{{Cite pmid|32507409 }}</ref> Consensus summary report for CEPI/BC March 12-13, 2020 meeting: Assessment of risk of disease enhancement with COVID-19 vaccines #MMPMID32507409 Lambert PH ; Ambrosino DM ; Andersen SR ; Baric RS ; Black SB ; Chen RT ; Dekker CL ; Didierlaurent AM ; Graham BS ; Martin SD ; Molrine DC ; Perlman S ; Picard-Fraser PA ; Pollard AJ ; Qin C ; Subbarao K ; Cramer JP Vaccine 2020[Jun]; 38 (31 ): 4783-4791 PMID32507409 show ga A novel coronavirus (CoV), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in late 2019 in Wuhan, China and has since spread as a global pandemic. Safe and effective vaccines are thus urgently needed to reduce the significant morbidity and mortality of Coronavirus Disease 2019 (COVID-19) disease and ease the major economic impact. There has been an unprecedented rapid response by vaccine developers with now over one hundred vaccine candidates in development and at least six having reached clinical trials. However, a major challenge during rapid development is to avoid safety issues both by thoughtful vaccine design and by thorough evaluation in a timely manner. A syndrome of "disease enhancement" has been reported in the past for a few viral vaccines where those immunized suffered increased severity or death when they later encountered the virus or were found to have an increased frequency of infection. Animal models allowed scientists to determine the underlying mechanism for the former in the case of Respiratory syncytial virus (RSV) vaccine and have been utilized to design and screen new RSV vaccine candidates. Because some Middle East respiratory syndrome (MERS) and SARS-CoV-1 vaccines have shown evidence of disease enhancement in some animal models, this is a particular concern for SARS-CoV-2 vaccines. To address this challenge, the Coalition for Epidemic Preparedness Innovations (CEPI) and the Brighton Collaboration (BC) Safety Platform for Emergency vACcines (SPEAC) convened a scientific working meeting on March 12 and 13, 2020 of experts in the field of vaccine immunology and coronaviruses to consider what vaccine designs could reduce safety concerns and how animal models and immunological assessments in early clinical trials can help to assess the risk. This report summarizes the evidence presented and provides considerations for safety assessment of COVID-19 vaccine candidates in accelerated vaccine development. |Animals [MESH] |Antibodies, Viral/*adverse effects/*immunology [MESH] |Betacoronavirus/*immunology/pathogenicity [MESH] |COVID-19 [MESH] |COVID-19 Vaccines [MESH] |Clinical Trials as Topic [MESH] |Coronavirus Infections/*immunology/prevention & control/virology [MESH] |Disease Models, Animal [MESH] |Humans [MESH] |Pandemics [MESH] |Pneumonia, Viral/*immunology/virology [MESH] |Risk Assessment [MESH] |SARS-CoV-2 [MESH] |Severe Acute Respiratory Syndrome/immunology [MESH]Consensus summary report for CEPI/BC March 12-13, 2020 meeting: Assess(epmc).pdf DeepDyve Pubget Overpricing