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2020 ; 548
(ä): 1-5
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Recovery of severely ill COVID-19 patients by intravenous immunoglobulin (IVIG)
treatment: A case series
#MMPMID32530808
Mohtadi N
; Ghaysouri A
; Shirazi S
; Sara Ansari
; Shafiee E
; Bastani E
; Kokhazadeh T
; Tavan H
Virology
2020[Sep]; 548
(ä): 1-5
PMID32530808
show ga
INTRODUCTION: During the recent months, COVID-19 has turned to a global crisis
claiming high mortality and morbidity among populations. Despite the high
prevalence of the disease, it has currently no definitive treatment. We here
reported the effects of intravenous immunoglobulin (IVIG) administration in
severely ill COVID-19 patients diagnosed based on PCR and radiology tests. CASE
PRESENTATION: Five severely ill COVID-19 patients in whom standard treatments
failed were administrated with IVIG which prevented the deterioration of clinical
symptoms. All the patients were treated with high-dose IVIG (0.3-0.5 g/kg) for 5
consecutive days so that no patient would receive lower than 25 g of the drug.
All the patients showed a desirable therapeutic response and were discharged from
the hospital with a stable clinical condition after being recovered. CONCLUSION:
Treatment with IVIG at the therapeutic dose of 0.3-0.5 g/kg can improve the
clinical condition and O2 saturation and prevent the progression of pulmonary
lesions in COVID-19 patients with severe symptoms in whom standard treatments
have failed.