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10.3390/ijms21093179 http://scihub22266oqcxt.onion/10.3390/ijms21093179 C7247444!7247444 !32365944     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32365944 &cmd=llinks): Failed to open stream: HTTP request failed! 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SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary Inflammation |pdf=|usr=}}{{32365944 }} gab.com Text SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary Inflammation JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32365944 #FOAvip Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) initiates the cytokine/chemokine storm-mediated lung injury. The SARS-CoV unique domain (SUD) with three macrodomains (N, M, and C), showing the G-quadruplex binding activity, was examined the possible role in SARS pathogenesis in this study. The chemokine profile analysis indicated that SARS-CoV SUD significantly up-regulated the expression of CXCL10, CCL5 and interleukin (IL)-1? in human lung epithelial cells and in the lung tissues of the mice intratracheally instilled with the recombinant plasmids. Among the SUD subdomains, SUD-MC substantially activated AP-1-mediated CXCL10 expression in vitro. In the wild type mice, SARS-CoV SUD-MC triggered the pulmonary infiltration of macrophages and monocytes, inducing CXCL10-mediated inflammatory responses and severe diffuse alveolar damage symptoms. Moreover, SUD-MC actuated NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome-dependent pulmonary inflammation, as confirmed by the NLRP3 inflammasome inhibitor and the NLRP3(-/-) mouse model. This study demonstrated that SARS-CoV SUD modulated NLRP3 inflammasome-dependent CXCL10-mediated pulmonary inflammation, providing the potential therapeutic targets for developing the antiviral agents. Twit Text FOAVip SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary Inflammation ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32365944 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32365944 #FOAvip English Wikipedia <ref>{{Cite pmid|32365944 }}</ref> SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary Inflammation #MMPMID32365944 Chang YS ; Ko BH ; Ju JC ; Chang HH ; Huang SH ; Lin CW Int J Mol Sci 2020[Apr]; 21 (9 ): ä PMID32365944 show ga Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) initiates the cytokine/chemokine storm-mediated lung injury. The SARS-CoV unique domain (SUD) with three macrodomains (N, M, and C), showing the G-quadruplex binding activity, was examined the possible role in SARS pathogenesis in this study. The chemokine profile analysis indicated that SARS-CoV SUD significantly up-regulated the expression of CXCL10, CCL5 and interleukin (IL)-1? in human lung epithelial cells and in the lung tissues of the mice intratracheally instilled with the recombinant plasmids. Among the SUD subdomains, SUD-MC substantially activated AP-1-mediated CXCL10 expression in vitro. In the wild type mice, SARS-CoV SUD-MC triggered the pulmonary infiltration of macrophages and monocytes, inducing CXCL10-mediated inflammatory responses and severe diffuse alveolar damage symptoms. Moreover, SUD-MC actuated NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome-dependent pulmonary inflammation, as confirmed by the NLRP3 inflammasome inhibitor and the NLRP3(-/-) mouse model. This study demonstrated that SARS-CoV SUD modulated NLRP3 inflammasome-dependent CXCL10-mediated pulmonary inflammation, providing the potential therapeutic targets for developing the antiviral agents. |Animals [MESH] |Bronchoalveolar Lavage Fluid/chemistry/immunology [MESH] |Cell Line [MESH] |Chemokine CXCL10/genetics/*metabolism [MESH] |Disease Models, Animal [MESH] |Humans [MESH] |Inflammasomes/*metabolism [MESH] |Lung/metabolism/pathology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Monocytes/immunology/metabolism [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/deficiency/genetics/*metabolism [MESH] |Pneumonia/pathology/virology [MESH] |Promoter Regions, Genetic [MESH] |Severe Acute Respiratory Syndrome/pathology/virology [MESH] |Severe acute respiratory syndrome-related coronavirus/isolation & purification/*metabolism [MESH] |Up-Regulation [MESH]SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavi(epmc).pdf DeepDyve Pubget Overpricing