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Label-Free Electrochemical Detection of DNA Hybridization: A Method for COVID-19
Diagnosis
#MMPMID38624377
Tripathy S
; Singh SG
Trans Indian Natl Acad Eng
2020[]; 5
(2
): 205-209
PMID38624377
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This paper presents label-free electrochemical transduction as a suitable scheme
for COVID-19-specific viral RNA/c-DNA detection, with an aim to facilitate point
of care diagnosis. In lieu of this, we discuss the proposed electrochemical
biosensing scheme, based on electrodeposited gold nanoparticles as the
transducing elements. Specific to this approach, here, the protocols associated
with the immobilization of the single-stranded probe nucleotide on to the
biosensor, have also been laid out. This paper also discusses the methods of
electrochemical analysis, to be used for data acquisition and subsequent
calibration, in relation to target analyte detection. Towards facilitating
portable diagnosis, development of miniaturized sensors and their integration
with readout units have also been discussed.
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