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10.1007/s40265-020-01321-z

http://scihub22266oqcxt.onion/10.1007/s40265-020-01321-z
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C7246970!7246970!32451923
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suck abstract from ncbi


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pmid32451923      Drugs 2020 ; 80 (10): 941-6
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  • The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19 #MMPMID32451923
  • Panera N; Tozzi AE; Alisi A
  • Drugs 2020[]; 80 (10): 941-6 PMID32451923show ga
  • G-Quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA. G4 sequences/structures have been detected in human and in viral genomes, including Coronaviruses Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2. Here, we outline the existing evidence indicating that G4 ligands and inhibitors of SARS-CoV-2 helicase may exert some antiviral activity reducing viral replication and can represent a potential therapeutic approach to tackle the COVID-19 pandemic due to SARS-CoV-2 infection. We also discuss how repositioning of FDA-approved drugs against helicase activity of other viruses, could represent a rapid strategy to limit deaths associated with COVID-19 pandemic.
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