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10.1093/ckj/sfaa083

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C7239220!7239220!32695324
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suck abstract from ncbi


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pmid32695324      Clin+Kidney+J 2020 ; 13 (3): 340-6
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  • Kidney manifestations of mild, moderate and severe coronavirus disease 2019: a retrospective cohort study #MMPMID32695324
  • Hong D; Long L; Wang AY; Lei Y; Tang Y; Zhao JW; Song X; He Y; Wen E; Zheng L; Li G; Wang L
  • Clin Kidney J 2020[Jun]; 13 (3): 340-6 PMID32695324show ga
  • Background: Coronavirus disease 2019 (COVID-19) is a pandemic that has affected more than 3 million patients globally. Previous data from Wuhan city showed that acute kidney injury (AKI), proteinuria and hematuria occurred frequently in patients with severe COVID-19. However, the prevalence of kidney injury in milder cases remains unclear. Methods: This retrospective study included two major consecutive cohorts of COVID-19 patients in Sichuan Province. Baseline characteristics, laboratory data including renal function, proteinuria and dipstick hematuria, and other laboratory parameters were collected. A subgroup of patients was followed up for 2?4?weeks to evaluate the short-term outcome of renal impairment. Results: Overall, 168 COVID-19-positive patients were included in the study. The majority of patients (79.7%) were diagnosed with mild or moderate disease. Half of patients presented with fever; however, in The Tibetan cohort, fever only occurred in 13.4% of patients. On hospital admission, proteinuria and dipstick hematuria were noted in 18.4% and 17.4% of patients, respectively, while AKI only occurred in one patient. Further analysis showed that severe or critical COVID-19 was associated with higher risk of proteinuria [relative risk (RR) 7.37, 95% confidence interval (CI) 2.45?22.18, P?=?3.8?×?10?4] and dipstick hematuria (RR 8.30, 95% CI 2.69?25.56, P?=?2.3?×?10?4). Proteinuria, dipstick hematuria, or the combination of proteinuria and hematuria could significantly predict severe or critical severe COVID-19. Conclusions: Proteinuria and dipstick hematuria are not uncommon in patients with COVID-19 infection, especially in severe or critical cases.
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