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10.1093/function/zqaa002 http://scihub22266oqcxt.onion/10.1093/function/zqaa002 C7239187!7239187!33215159     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Function+(Oxf) 2020 ; 1 (1): ä Nephropedia Template TP {{tp|p=33215159|t=2020. Potential Role of Oral Rinses Targeting the Viral Lipid Envelope in SARS-CoV-2 Infection |pdf=|usr=}}{{33215159}} gab.com Text Potential Role of Oral Rinses Targeting the Viral Lipid Envelope in SARS-CoV-2 Infection JO: Function (Oxf) http://www.kidney.de/pget.php?&tw=1&pmid=33215159 #FOAvip Emerging studies increasingly demonstrate the importance of the throat and salivary glands as sites of virus replication and transmission in early COVID-19 disease. SARS-CoV-2 is an enveloped virus, characterized by an outer lipid membrane derived from the host cell from which it buds. While it is highly sensitive to agents that disrupt lipid biomembranes, there has been no discussion about the potential role of oral rinsing in preventing transmission. Here, we review known mechanisms of viral lipid membrane disruption by widely available dental mouthwash components that include ethanol, chlorhexidine, cetylpyridinium chloride, hydrogen peroxide, and povidone-iodine. We also assess existing formulations for their potential ability to disrupt the SARS-CoV-2 lipid envelope, based on their concentrations of these agents, and conclude that several deserve clinical evaluation. We highlight that already published research on other enveloped viruses, including coronaviruses, directly supports the idea that oral rinsing should be considered as a potential way to reduce transmission of SARS-CoV-2. Research to test this could include evaluating existing or specifically tailored new formulations in well-designed viral inactivation assays, then in clinical trials. Population-based interventions could be undertaken with available mouthwashes, with active monitoring of outcome to determine efficacy. This is an under-researched area of major clinical need. Twit Text FOAVip Potential Role of Oral Rinses Targeting the Viral Lipid Envelope in SARS-CoV-2 Infection ????Function (Oxf) http://www.kidney.de/pget.php?&tw=1&pmid=33215159 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33215159 #FOAvip English Wikipedia <ref>{{Cite pmid|33215159}}</ref> Potential Role of Oral Rinses Targeting the Viral Lipid Envelope in SARS-CoV-2 Infection #MMPMID33215159 O?Donnell VB; Thomas D; Stanton R; Maillard JY; Murphy RC; Jones SA; Humphreys I; Wakelam MJO; Fegan C; Wise MP; Bosch A; Sattar SA Function (Oxf) 2020[]; 1 (1): ä PMID33215159show ga Emerging studies increasingly demonstrate the importance of the throat and salivary glands as sites of virus replication and transmission in early COVID-19 disease. SARS-CoV-2 is an enveloped virus, characterized by an outer lipid membrane derived from the host cell from which it buds. While it is highly sensitive to agents that disrupt lipid biomembranes, there has been no discussion about the potential role of oral rinsing in preventing transmission. Here, we review known mechanisms of viral lipid membrane disruption by widely available dental mouthwash components that include ethanol, chlorhexidine, cetylpyridinium chloride, hydrogen peroxide, and povidone-iodine. We also assess existing formulations for their potential ability to disrupt the SARS-CoV-2 lipid envelope, based on their concentrations of these agents, and conclude that several deserve clinical evaluation. We highlight that already published research on other enveloped viruses, including coronaviruses, directly supports the idea that oral rinsing should be considered as a potential way to reduce transmission of SARS-CoV-2. Research to test this could include evaluating existing or specifically tailored new formulations in well-designed viral inactivation assays, then in clinical trials. Population-based interventions could be undertaken with available mouthwashes, with active monitoring of outcome to determine efficacy. This is an under-researched area of major clinical need. äPotential Role of Oral Rinses Targeting the Viral Lipid Envelope in SA(epmc).pdf DeepDyve Pubget Overpricing