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2020 ; 22
(4-5
): 200-205
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gab.com Text
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Arbidol/IFN-?2b therapy for patients with corona virus disease 2019: a
retrospective multicenter cohort study
#MMPMID32445881
Xu P
; Huang J
; Fan Z
; Huang W
; Qi M
; Lin X
; Song W
; Yi L
Microbes Infect
2020[May]; 22
(4-5
): 200-205
PMID32445881
show ga
The spread of COVID-19 is accelerating. At present, there is no specific
antiviral drugs for COVID-19 outbreak. This is a multicenter retrospective cohort
study of patients with laboratory-confirmed COVID-19 infection pneumonia from 3
hospitals in Hubei and Guangdong province, 141 adults (aged ?18 years) without
ventilation were included. Combined group patients were given Arbidol and
IFN-?2b, monotherapy group patients inhaled IFN-?2b for 10-14 days. Of 141
COVID-19 patients, baseline clinical and laboratory characteristics were similar
between combined group and monotherapy group, that 30% of the patients leucocytes
counts were below the normal range and 36.4% of the patients experienced
lymphocytopenia. The duration of viral RNA of respiratory tract in the
monotherapy group was not longer than that in the combined therapy group. There
was no significant differences between two groups. The absorption of pneumonia in
the combined group was faster than that in the monotherapy group. We inferred
that Arbidol/IFN - 2 b therapy can be used as an effective method to improve the
COVID-19 pneumonia of mild patients, although it helpless with accelerating the
virus clearance. These results should be verified in a larger prospective
randomized environment.