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10.1053/j.gastro.2020.05.032 http://scihub22266oqcxt.onion/10.1053/j.gastro.2020.05.032 C7233252!7233252 !32425234     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32425234 &cmd=llinks): Failed to open stream: HTTP request failed! 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Corticosteroids, But Not TNF Antagonists, Are Associated With Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results From an International Registry |pdf=|usr=}}{{32425234 }} gab.com Text Corticosteroids, But Not TNF Antagonists, Are Associated With Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results From an International Registry JO: Gastroenterology http://www.kidney.de/pget.php?&tw=1&pmid=32425234 #FOAvip BACKGROUND AND AIMS: The impact of Coronavirus disease 2019 (COVID-19) on patients with inflammatory bowel disease (IBD) is unknown. We sought to characterize the clinical course of COVID-19 among patients with IBD and evaluate the association among demographics, clinical characteristics, and immunosuppressant treatments on COVID-19 outcomes. METHODS: Surveillance Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD) is a large, international registry created to monitor outcomes of patients with IBD with confirmed COVID-19. We calculated age-standardized mortality ratios and used multivariable logistic regression to identify factors associated with severe COVID-19, defined as intensive care unit admission, ventilator use, and/or death. RESULTS: 525 cases from 33 countries were reported (median age 43 years, 53% men). Thirty-seven patients (7%) had severe COVID-19, 161 (31%) were hospitalized, and 16 patients died (3% case fatality rate). Standardized mortality ratios for patients with IBD were 1.8 (95% confidence interval [CI], 0.9-2.6), 1.5 (95% CI, 0.7-2.2), and 1.7 (95% CI, 0.9-2.5) relative to data from China, Italy, and the United States, respectively. Risk factors for severe COVID-19 among patients with IBD included increasing age (adjusted odds ratio [aOR], 1.04; 95% CI, 1.01-1.02), ?2 comorbidities (aOR, 2.9; 95% CI, 1.1-7.8), systemic corticosteroids (aOR, 6.9; 95% CI, 2.3-20.5), and sulfasalazine or 5-aminosalicylate use (aOR, 3.1; 95% CI, 1.3-7.7). Tumor necrosis factor antagonist treatment was not associated with severe COVID-19 (aOR, 0.9; 95% CI, 0.4-2.2). CONCLUSIONS: Increasing age, comorbidities, and corticosteroids are associated with severe COVID-19 among patients with IBD, although a causal relationship cannot be definitively established. Notably, tumor necrosis factor antagonists do not appear to be associated with severe COVID-19. Twit Text FOAVip Corticosteroids, But Not TNF Antagonists, Are Associated With Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results From an International Registry ????Gastroenterology http://www.kidney.de/pget.php?&tw=1&pmid=32425234 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32425234 #FOAvip English Wikipedia <ref>{{Cite pmid|32425234 }}</ref> Corticosteroids, But Not TNF Antagonists, Are Associated With Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results From an International Registry #MMPMID32425234 Brenner EJ ; Ungaro RC ; Gearry RB ; Kaplan GG ; Kissous-Hunt M ; Lewis JD ; Ng SC ; Rahier JF ; Reinisch W ; Ruemmele FM ; Steinwurz F ; Underwood FE ; Zhang X ; Colombel JF ; Kappelman MD Gastroenterology 2020[Aug]; 159 (2 ): 481-491.e3 PMID32425234 show ga BACKGROUND AND AIMS: The impact of Coronavirus disease 2019 (COVID-19) on patients with inflammatory bowel disease (IBD) is unknown. We sought to characterize the clinical course of COVID-19 among patients with IBD and evaluate the association among demographics, clinical characteristics, and immunosuppressant treatments on COVID-19 outcomes. METHODS: Surveillance Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD) is a large, international registry created to monitor outcomes of patients with IBD with confirmed COVID-19. We calculated age-standardized mortality ratios and used multivariable logistic regression to identify factors associated with severe COVID-19, defined as intensive care unit admission, ventilator use, and/or death. RESULTS: 525 cases from 33 countries were reported (median age 43 years, 53% men). Thirty-seven patients (7%) had severe COVID-19, 161 (31%) were hospitalized, and 16 patients died (3% case fatality rate). Standardized mortality ratios for patients with IBD were 1.8 (95% confidence interval [CI], 0.9-2.6), 1.5 (95% CI, 0.7-2.2), and 1.7 (95% CI, 0.9-2.5) relative to data from China, Italy, and the United States, respectively. Risk factors for severe COVID-19 among patients with IBD included increasing age (adjusted odds ratio [aOR], 1.04; 95% CI, 1.01-1.02), ?2 comorbidities (aOR, 2.9; 95% CI, 1.1-7.8), systemic corticosteroids (aOR, 6.9; 95% CI, 2.3-20.5), and sulfasalazine or 5-aminosalicylate use (aOR, 3.1; 95% CI, 1.3-7.7). Tumor necrosis factor antagonist treatment was not associated with severe COVID-19 (aOR, 0.9; 95% CI, 0.4-2.2). CONCLUSIONS: Increasing age, comorbidities, and corticosteroids are associated with severe COVID-19 among patients with IBD, although a causal relationship cannot be definitively established. Notably, tumor necrosis factor antagonists do not appear to be associated with severe COVID-19. |*Population Surveillance [MESH] |Adrenal Cortex Hormones/*adverse effects [MESH] |Adult [MESH] |Aged [MESH] |Betacoronavirus [MESH] |COVID-19 [MESH] |Comorbidity [MESH] |Coronavirus Infections/chemically induced/*mortality/virology [MESH] |Critical Care/statistics & numerical data [MESH] |Female [MESH] |Hospitalization/statistics & numerical data [MESH] |Humans [MESH] |Immunosuppressive Agents/*adverse effects [MESH] |Inflammatory Bowel Diseases/*drug therapy/mortality/virology [MESH] |Male [MESH] |Middle Aged [MESH] |Odds Ratio [MESH] |Pandemics [MESH] |Pneumonia, Viral/chemically induced/*mortality/virology [MESH] |Registries [MESH] |Respiration, Artificial/statistics & numerical data [MESH] |Risk Factors [MESH] |SARS-CoV-2 [MESH] |Sulfasalazine/adverse effects [MESH]Corticosteroids, But Not TNF Antagonists, Are Associated With Adverse (epmc).pdf DeepDyve Pubget Overpricing