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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Biochem+Mol+Biol+Educ
2004 ; 32
(6
): 395-9
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Solving an ethical issue involved in experimentation with animals in a brazilian
teaching laboratory*
#MMPMID21706763
Loureiro NI
; Viana HV
; Rodrigues CR
; Cabral LM
; Silva TD
; Cardoso FS
; Santos DO
; Castro HC
Biochem Mol Biol Educ
2004[Nov]; 32
(6
): 395-9
PMID21706763
show ga
Changes are occurring within Brazilian institutes of higher education; currently
several universities are reviewing their course offerings and teaching approaches
to determine if they meet the needs of today's undergraduate students. When
changes are made to the curriculum of experimental courses, there should be an
understood guarantee that all efforts to avoid ethical and biosafety issues have
been diligently considered. Ethical considerations lead us to create an
alternative experimental session to be conducted that eliminated the use of rats,
the conventional in vivo model employed for learning metabolism of glycogen in
our university. To avoid possible biosafety issues, we prepared an alternative
sample to simulate human urine, which we called guarurine. Using our new method,
it is possible to verify positive results imitating a diabetic and starving
people samples for detection of glucose and ketone. The alternative tool
described herein is not only particularly suited to bypass the ethics of using
animals for teaching, but also permits the discussion of significant aspects of
pathological and physiological situations such as diabetics and starvation in a
simple, safe, and interesting way.