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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Gynecol+Oncol
2020 ; 158
(1
): 37-43
Nephropedia Template TP
gab.com Text
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English Wikipedia
Wait-time for hysterectomy and survival of women with early-stage cervical
cancer: A clinical implication during the coronavirus pandemic
#MMPMID32425268
Matsuo K
; Novatt H
; Matsuzaki S
; Hom MS
; Castaneda AV
; Licon E
; Nusbaum DJ
; Roman LD
Gynecol Oncol
2020[Jul]; 158
(1
): 37-43
PMID32425268
show ga
OBJECTIVE: A global pandemic caused by a novel coronavirus (Covid-19) has created
unique challenges to providing timely care for cancer patients. In early-stage
cervical cancer, postponing hysterectomy for 6-8 weeks is suggested as a possible
option in the Covid-19 burdened hospitals. Yet, literature examining the impact
of surgery wait-time on survival in early-stage cervical cancer remains scarce.
This study examined the association between surgery wait-time of 8 weeks and
oncologic outcome in women with early-stage cervical cancer. METHODS: This is a
single institution retrospective observational study at a tertiary referral
medical center examining women who underwent primary hysterectomy or
trachelectomy for clinical stage IA-IIA invasive cervical cancer between 2000 and
2017 (N = 217). Wait-time from the diagnosis of invasive cervical cancer via
biopsy to definitive surgery was categorized as: short wait-time (<8 weeks;
n = 110) versus long wait-time (?8 weeks; n = 107). Propensity score inverse
probability of treatment weighting was used to balance the measured demographics
between the two groups, and disease-free survival (DFS) and overall survival (OS)
were assessed. A systematic literature review with meta-analysis was additionally
performed. RESULTS: In a weighted model (median follow-up, 4.6 years), women in
the long wait-time group had DFS (4.5-year rates, 91.2% versus 90.7%, hazard
ratio [HR] 1.11, 95% confidence interval [CI] 0.47-2.59, P = 0.818) and OS (95.0%
versus 97.4%, HR 1.47, 95%CI 0.50-4.31, P = 0.487) similar to those in the short
wait-time group. Three studies were examined for meta-analysis, and a pooled HR
for surgery wait-time of ?8 weeks on DFS was 0.96 (95%CI 0.59-1.55). CONCLUSION:
Our study suggests that wait-time of 8 weeks for hysterectomy may not be
associated with short-term disease recurrence in women with early-stage cervical
cancer.
|Adult
[MESH]
|Aged
[MESH]
|Betacoronavirus/isolation & purification
[MESH]
|COVID-19
[MESH]
|California/epidemiology
[MESH]
|Coronavirus Infections/*epidemiology
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Hysterectomy/methods/*statistics & numerical data
[MESH]
|Middle Aged
[MESH]
|Pandemics
[MESH]
|Pneumonia, Viral/*epidemiology
[MESH]
|Propensity Score
[MESH]
|Retrospective Studies
[MESH]
|SARS-CoV-2
[MESH]
|Tertiary Care Centers/statistics & numerical data
[MESH]
|Time-to-Treatment/*statistics & numerical data
[MESH]