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2020 ; 143
(ä): 109842
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Reflection on lower rates of COVID-19 in children: Does childhood immunizations
offer unexpected protection?
#MMPMID32425304
Lyu J
; Miao T
; Dong J
; Cao R
; Li Y
; Chen Q
Med Hypotheses
2020[Oct]; 143
(ä): 109842
PMID32425304
show ga
The incidence of COVID-19 in children and teenagers is only about 2% in China.
Children had mild symptoms and hardly infected other children or adults. It is
worth considering that children are the most vulnerable to respiratory pathogens,
but fatal SARS-like virus had not caused severe cases among them. According to
the pathological studies of COVID-19 and SARS, a sharp decrease in T lymphocytes
leads to the breakdown of the immune system. The cellular immune system of
children differs from that of adults may be the keystone of atypical clinical
manifestations or even covert infection. The frequent childhood vaccinations and
repeated pathogens infections might be resulting in trained immunity of innate
immune cells, immune fitness of adaptive immune cells or cross-protection of
antibodies in the children. Therefore, due to lack of specific vaccine, some
vaccines for tuberculosis, influenza and pneumonia may have certain application
potential for the front-line health workers in the prevention and control of
COVID-19. However, for high-risk susceptible populations, such as the elderly
with basic diseases such as hypertension and diabetes, it is necessary to explore
the remedial effect of the planned immune process on their immunity to achieve
the trained immunity or immune fitness, so as to improve their own antiviral
ability.
|*Vaccination
[MESH]
|Adolescent
[MESH]
|Antibodies, Viral/immunology
[MESH]
|Betacoronavirus
[MESH]
|COVID-19
[MESH]
|Child
[MESH]
|Child, Preschool
[MESH]
|China/epidemiology
[MESH]
|Coinfection
[MESH]
|Coronavirus Infections/*epidemiology/*prevention & control
[MESH]
|Humans
[MESH]
|Immunization Programs
[MESH]
|Infant
[MESH]
|Pandemics/*prevention & control
[MESH]
|Pneumonia, Viral/*epidemiology/*prevention & control
[MESH]