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2021 ; 126
(1
): 142-146
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Short fractionation radiotherapy for early prostate cancer in the time of
COVID-19: long-term excellent outcomes from a multicenter Italian trial suggest a
larger adoption in clinical practice
#MMPMID32415472
Barra S
; Guarnieri A
; di Monale E Bastia MB
; Marcenaro M
; Tornari E
; Belgioia L
; Magrini SM
; Ricardi U
; Corvò R
Radiol Med
2021[Jan]; 126
(1
): 142-146
PMID32415472
show ga
INTRODUCTION: To evaluate stereotactic body radiotherapy (SBRT) in low-risk
Prostate Cancer patients as preferred treatment option in emergency health
conditions. MATERIALS AND METHODS: From April 2013 to September 2015, 28 patients
with low-risk prostate cancer were prospectively enrolled. The SBRT prescribed
dose was 36.25 Gy in 5 fractions, twice a week. Primary endpoints were acute and
late toxicity. Secondary endpoints were biochemical recurrence free survival
(bRFS) and overall survival. RESULTS: Median follow-up was 65.5 months (range
52-81). No acute G3 or G4 toxicity was recorded. Acute G1 or G2 genitourinary
(GU) toxicity occurred in 43% and acute G1-G2 gastrointestinal (GI) toxicity in
14%. Late G1 and G3 GU toxicity in 18% and 3.5%, respectively. The G3 toxicity
was not directly attributable to radiotherapy. Late G1 GI toxicity occurred in
18%. 5yy bRFS was 96.5% (95% CI 82.3-99.4%). CONCLUSIONS: Stereotactic body
radiotherapy for early prostate cancer reported safe toxicity profile and a good
clinical outcome at the median follow-up of 5 years. It may be an useful option
if radiotherapy is required in emergency medical conditions.