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2020 ; 40
(4
): 586-594
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Chloroquine phosphate: therapeutic drug for COVID-19
#MMPMID32895128
Mo L
; Zheng P
Nan Fang Yi Ke Da Xue Xue Bao
2020[Apr]; 40
(4
): 586-594
PMID32895128
show ga
Since the outbreak of coronavirus disease 2019 (COVID-19) in the late 2019, a
variety of antiviral drugs have been used in the first-line clinical trial. The
Diagnostic and Treatment Protocol for COVID-19 (Trial Version 6) in China
recommends chloroquine phosphate for the first time as an anti-coronavirus trial
drug. As a classic drug for treatment of malaria and rheumatism, chloroquine
phosphate has been used clinically for more than 80 years, and has also shown
good results in the treatment of various viral infections. As the plasma drug
concentration varies greatly among different races and individuals and due to its
narrow treatment window, chloroquine in likely to accumulate in the body to cause
toxicity. Among the treatment regimens recommended for COVID-19, reports
concerning the safety of a short-term high-dose chloroquine regimen remain
scarce. In this review, the authors summarize the current research findings of
chloroquine phosphate in the treatment of COVID-19, and examine the
pharmacokinetic characteristics, antiviral therapy, the therapeutic mechanism and
safety of chloroquine.
|*Coronavirus Infections/drug therapy
[MESH]
|*Pandemics
[MESH]
|*Pneumonia, Viral/drug therapy
[MESH]
|Antiviral Agents
[MESH]
|Betacoronavirus/*drug effects
[MESH]
|COVID-19
[MESH]
|COVID-19 Drug Treatment
[MESH]
|China
[MESH]
|Chloroquine/*analogs & derivatives/therapeutic use
[MESH]