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2020 ; 40
(4
): 601-605
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Application of laboratory diagnostic technologies for SARS-CoV-2: current
progress and prospect
#MMPMID32895122
Xiao B
; Zhou Q
; Lei T
; He Y
; Li L
Nan Fang Yi Ke Da Xue Xue Bao
2020[Apr]; 40
(4
): 601-605
PMID32895122
show ga
Since the outbreak of COVID-19 pandemic, the detection capability has been
improving and the detection techniques have been evolving with innovations. qRT-
PCR and mNGS, which represent the current mainstay diagnostic technologies, play
key roles in disease diagnosis and monitoring of virus variation. The detection
technologies based on serum and plasma IgM and IgG antibodies are important for
auxiliary diagnosis. RT-LAMP is highly specific for a diagnostic purpose. Digital
PCR could quantitatively detect nucleic acid and SHERLOCK has a higher
sensitivity. These techniques all have great potential for future development and
application for pathogen detection. In this review the authors summarize the
basic rationales, technical characteristics and the current application of the
SARS-CoV-2 detection techniques.
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