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2020 ; 38
(6
): 775-780
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Evidence-based best practice advice for patients treated with systemic
immunosuppressants in relation to COVID-19
#MMPMID32419721
Galimberti F
; McBride J
; Cronin M
; Li Y
; Fox J
; Abrouk M
; Herbst A
; Kirsner RS
Clin Dermatol
2020[Nov]; 38
(6
): 775-780
PMID32419721
show ga
The emergence of the COVID-19 pandemic has led to significant uncertainty among
physicians and patients about the safety of immunosuppressive medications used
for the management of dermatologic conditions. We review available data on
commonly used immunosuppressants and their effect on viral infections beyond
COVID-19. Notably, the effect of some immunosuppressants on viruses related to
SARS-CoV2, including SARS and MERS, has been previously investigated. In the
absence of data on the effect of immunosuppressants on COVID-19, these data could
be used to make clinical decisions on initiation and continuation of
immunosuppressive medications during this pandemic. In summary, we recommend
considering the discontinuation of oral Janus kinase (JAK) inhibitors and
prednisone; considering the delay of rituximab infusion; and suggesting the
careful continuation of cyclosporine, mycophenolate, azathioprine, methotrexate,
and biologics in patients currently benefitting from such treatments.