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2020 ; 7
(ä): 171
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Evaluation of the Secondary Transmission Pattern and Epidemic Prediction of
COVID-19 in the Four Metropolitan Areas of China
#MMPMID32574319
Su L
; Hong N
; Zhou X
; He J
; Ma Y
; Jiang H
; Han L
; Chang F
; Shan G
; Zhu W
; Long Y
Front Med (Lausanne)
2020[]; 7
(ä): 171
PMID32574319
show ga
Understanding the transmission dynamics of COVID-19 is crucial for evaluating its
spread pattern, especially in metropolitan areas of China, as its spread could
lead to secondary outbreaks. In addition, the experiences gained and lessons
learned from China have the potential to provide evidence to support other
metropolitan areas and large cities outside China with their emerging cases. We
used data reported from January 24, 2020, to February 23, 2020, to fit a model of
infection, estimate the likely number of infections in four high-risk
metropolitan areas based on the number of cases reported, and increase the
understanding of the COVID-19 spread pattern. Considering the effect of the
official quarantine regulations and travel restrictions for China, which began
January 23~24, 2020, we used the daily travel intensity index from the Baidu Maps
app to roughly simulate the level of restrictions and estimate the proportion of
the quarantined population. A group of SEIR model statistical parameters were
estimated using Markov chain Monte Carlo (MCMC) methods and fitting on the basis
of reported data. As a result, we estimated that the basic reproductive number, R
(0), was 2.91 in Beijing, 2.78 in Shanghai, 2.02 in Guangzhou, and 1.75 in
Shenzhen based on the data from January 24, 2020, to February 23, 2020. In
addition, we inferred the prediction results and compared the results of
different levels of parameters. For example, in Beijing, the predicted peak
number of cases was 467 with a peak time of March 01, 2020; however, if the city
were to implement different levels (strict, moderate, or weak) of travel
restrictions or regulation measures, the estimation results showed that the
transmission dynamics would change and that the peak number of cases would differ
by between 54% and 209%. We concluded that public health interventions would
reduce the risk of the spread of COVID-19 and that more rigorous control and
prevention measures would effectively contain its further spread, and awareness
of prevention should be enhanced when businesses and social activities return to
normal before the end of the epidemic. Further, the experiences gained and
lessons learned from China offer the potential to provide evidence supporting
other metropolitan areas and big cities with their emerging cases outside China.