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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Nutr+Health+Aging
2020 ; 24
(6
): 550-559
Nephropedia Template TP
gab.com Text
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COVID-19: A Personalized Cardiometabolic Approach for Reducing Complications and
Costs The Role of Aging beyond Topics
#MMPMID32510105
Saban-Ruiz J
; Ly-Pen D
J Nutr Health Aging
2020[]; 24
(6
): 550-559
PMID32510105
show ga
COVID 19 is much more than an infectious disease by SARS-CoV-2 followed by a
disproportionate immune response. An older age, diabetes and history of
cardiovascular disease, especially hypertension, but also chronic heart failure
and coronary artery disease among others, are between the most important risk
factors. In addition, during the hospitalization both hyperglycaemia and heart
failure are frequent. Less frequent are acute coronary syndrome, arrhythmias and
stroke. Accordingly, not all prolonged stays or even deaths are due directly to
SARS-CoV-2. To our knowledge, this is the first review, focusing both on
cardiovascular and metabolic aspects of this dreadful disease, in an integrated
and personalized way, following the guidelines of the Cardiometabolic
Health/Medicine. Therefore, current personalized aspects such as ACEIs and ARBs,
the place of statins and the most appropriate management of heart failure in
diabetics are analysed. Aging, better than old age, as a dynamic process, is also
considered in this review for the first time in the literature, and not only as a
risk factor attributed to cardiovascular and non-cardiovascular comorbidities.
Immunosenescence is also approached to build healthier elders, so they can resist
present and future infectious diseases, and not only in epidemics or pandemics.
In addition, to do this we must start knowing the molecular mechanisms that
underlying Aging process in general, and immunosenescence in particular.
Surprisingly, the endoplasmic reticulum stress and autophagy are implicated in
both process. Finally, with a training in all the aspects covered in this review,
not only the hospital stay, complications and costs of this frightening disease
in high-risk population should be reduced. Likely, this paper will open a gate to
the future for open-minded physicians.