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2020 ; 18
(1
): 196
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gab.com Text
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Allo-priming as a universal anti-viral vaccine: protecting elderly from current
COVID-19 and any future unknown viral outbreak
#MMPMID32398026
Har-Noy M
; Or R
J Transl Med
2020[May]; 18
(1
): 196
PMID32398026
show ga
BACKGROUND: We present the rationale for a novel allo-priming approach to serve
the elderly as a universal anti-virus vaccine, as well serving to remodel the
aging immune system in order to reverse immunosenescence and inflammaging. This
approach has the potential to protect the most vulnerable from disease and
provide society an incalculable economic benefit. Allo-priming healthy elderly
adults is proposed to provide universal protection from progression of any type
of viral infection, including protection against progression of the current
outbreak of COVID-19 infection, and any future variants of the causative
SARS-CoV-2 virus or the next 'Disease X'. Allo-priming is an alternative approach
for the COVID-19 pandemic that provides a back-up in case vaccination strategies
to elicit neutralizing antibody protection fails or fails to protect the
vulnerable elderly population. The allo-priming is performed using activated,
intentionally mismatched, ex vivo differentiated and expanded living Th1-like
cells (AlloStim(®)) derived from healthy donors currently in clinical use as an
experimental cancer vaccine. Multiple intradermal injections of AlloStim(®)
creates a dominate titer of allo-specific Th1/CTL memory cells in circulation,
replacing the dominance of exhausted memory cells of the aged immune system. Upon
viral encounter, by-stander activation of the allo-specific memory cells causes
an immediate release of IFN-?, leading to development of an "anti-viral state",
by-stander activation of innate cellular effector cells and activation of
cross-reactive allo-specific CTL. In this manner, the non-specific activation of
allo-specific Th1/CTL initiates a cascade of spatial and temporal immune events
which act to limit the early viral titer. The release of endogenous heat shock
proteins (HSP) and DAMP from lysed viral-infected cells, in the context of IFN-?,
creates of conditions for in situ vaccination leading to viral-specific Th1/CTL
immunity. These viral-specific Th1/CTL provide sterilizing immunity and memory
for protection from disease recurrence, while increasing the pool of Th1/CTL in
circulation capable of responding to the next viral encounter. CONCLUSION:
Allo-priming has potential to provide universal protection from viral disease and
is a strategy to reverse immunosenescence and counter-regulate chronic
inflammation (inflammaging). Allo-priming can be used as an adjuvant for
anti-viral vaccines and as a counter-measure for unknown biological threats and
bio-economic terrorism.
|*Betacoronavirus
[MESH]
|*Immunologic Memory
[MESH]
|*Viral Vaccines/immunology
[MESH]
|Adult
[MESH]
|Aged
[MESH]
|Antibodies, Neutralizing/immunology
[MESH]
|Antibodies, Viral/immunology
[MESH]
|Antigen Presentation
[MESH]
|COVID-19
[MESH]
|Coronavirus Infections/immunology/*prevention & control
[MESH]
|Humans
[MESH]
|Pandemics/*prevention & control
[MESH]
|Pneumonia, Viral/immunology/*prevention & control
[MESH]
free
free
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