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2020 ; 47
(9
): 2083-2089
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Novel coronavirus disease 2019 (COVID-19): relationship between chest CT scores
and laboratory parameters
#MMPMID32399620
Zhang B
; Zhang J
; Chen H
; Chen L
; Chen Q
; Li M
; Chen Z
; You J
; Yang K
; Zhang S
Eur J Nucl Med Mol Imaging
2020[Aug]; 47
(9
): 2083-2089
PMID32399620
show ga
PURPOSE: To quantify the severity of 2019 novel coronavirus disease (COVID-19) on
chest CT and to determine its relationship with laboratory parameters. METHODS:
Patients with real-time fluorescence polymerase chain reaction (RT-PCR)-confirmed
COVID-19 between January 01 and February 18, 2020, were included in this study.
Laboratory parameters were retrospectively collected from medical records.
Severity of lung changes on chest CT of early, progressive, peak, and absorption
stages was scored according to the percentage of lung involvement (5 lobes,
scores 1-5 for each lobe, range 0-20). Relationship between CT scores and
laboratory parameters was evaluated by the Spearman rank correlation. The
Bonferroni correction adjusted significance level was at 0.05/4?=?0.0125.
RESULTS: A total of 84 patients (mean age, 47.8?±?12.0 years [standard
deviation]; age range, 24-80 years) were evaluated. The patients underwent a
total of 339 chest CT scans with a median interval of 4 days (interquartile
range, 3-5 days). Median chest CT scores peaked at 4 days after the beginning of
treatment and then declined. CT score of the early stage was correlated with
neutrophil count (r?=?0.531, P?=?0.011). CT score of the progressive stage was
correlated with neutrophil count (r?=?0.502, P?0.001), white blood cell count
(r?=?0.414, P?=?0.001), C-reactive protein (r?=?0.511, P?0.001), procalcitonin
(r?=?0.423, P?=?0.004), and lactose dehydrogenase (r?=?0.369, P?=?0.010).
However, CT scores of the peak and absorption stages were not correlated with any
parameter (P?>?0.0125). No sex difference occurred regarding CT score (P?>?0.05).
CONCLUSION: Severity of lung abnormalities quantified on chest CT might correlate
with laboratory parameters in the early and progressive stages. However, larger
cohort studies are necessary.