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2020 ; 158
(ä): 104896
Nephropedia Template TP
gab.com Text
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English Wikipedia
Efficacy and Safety of Integrated Traditional Chinese and Western Medicine for
Corona Virus Disease 2019 (COVID-19): a systematic review and meta-analysis
#MMPMID32438037
Liu M
; Gao Y
; Yuan Y
; Yang K
; Shi S
; Zhang J
; Tian J
Pharmacol Res
2020[Aug]; 158
(ä): 104896
PMID32438037
show ga
Corona virus disease (COVID-19) has now spread to all parts of the world and
almost all countries are battling against it. This study aimed to assess the
efficacy and safety of Integrated Traditional Chinese and Western Medicine
(Hereinafter referred to as "Integrated Medicine") to COVID-19. We searched six
major Chinese and English databases to identify randomized controlled trials
(RCTs) and case-control studies (CCSs) of Integrated Medicine on COVID-19. Two
reviewers independently screened, identified studies, and extracted data.
Cochrane Risk of Bias tool and the Newcastle-Ottawa Scale were used to assess the
quality of included RCTs and CCSs, respectively. Stata (version 13.0; StataCorp)
was used to perform meta-analyses with the random-effects model. Risk ratio (RR)
was used for dichotomous data while the weighted mean difference (WMD) was
adopted for continuous variables as effect size, both of which were demonstrated
in effect size and 95% confidence intervals (CI). A total of 11 studies were
included. Four were RCTs and seven were CCSs. The sample size of including
studies ranged from 42 to 200 (total 982). The traditional Chinese medicine
included Chinese medicine compound drugs (QingFei TouXie FuZhengFang) and Chinese
patent medicine (e.g. Shufeng Jiedu Capsule, Lianhua Qingwen granules). Compared
with the control group, the overall response rate [RR?=?1.230, 95%CI (1.113,
1.359), P?=?0.000], cure rate [RR?=?1.604, 95%CI (1.181, 2.177), P?=?0.002],
severity illness rate [RR?=?0.350, 95%CI (0.154, 0.792), P?=?0.012], and hospital
stay [WMD?=?-1.991, 95%CI (-3.278, -0.703), P?=?0.002] of the intervention group
were better. In addition, Integrated Medicine can improve the disappearance rate
of fever, cough, expectoration, fatigue, chest tightness and anorexia and reduce
patients' fever, and fatigue time (P?0.05). This review found that Integrated
Medicine had better effects and did not increase adverse drug reactions for
COVID-19. More high-quality RCTs are needed in the future.