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2020 ; 130
(ä): 106680
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Angiotensin converting enzyme: A review on expression profile and its association
with human disorders with special focus on SARS-CoV-2 infection
#MMPMID32423553
Ghafouri-Fard S
; Noroozi R
; Omrani MD
; Branicki W
; Po?piech E
; Sayad A
; Pyrc K
; ?abaj PP
; Vafaee R
; Taheri M
; Sanak M
Vascul Pharmacol
2020[Jul]; 130
(ä): 106680
PMID32423553
show ga
Angiotensin-converting enzyme (ACE) and its homologue, ACE2, have been mostly
associated with hypertensive disorder. However, recent pandemia of SARS-CoV-2 has
put these proteins at the center of attention, as this virus has been shown to
exploit ACE2 protein to enter cells. Clear difference in the response of affected
patients to this virus has urged researchers to find the molecular basis and
pathophysiology of the cell response to this virus. Different levels of
expression and function of ACE proteins, underlying disorders, consumption of
certain medications and the existence of certain genomic variants within ACE
genes are possible explanations for the observed difference in the response of
individuals to the SARS-CoV-2 infection. In the current review, we discuss the
putative mechanisms for this observation.