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2020 ; 8
(7
): 448
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English Wikipedia
Imitation dynamics in the mitigation of the novel coronavirus disease (COVID-19)
outbreak in Wuhan, China from 2019 to 2020
#MMPMID32395492
Zhao S
; Stone L
; Gao D
; Musa SS
; Chong MKC
; He D
; Wang MH
Ann Transl Med
2020[Apr]; 8
(7
): 448
PMID32395492
show ga
BACKGROUND: The coronavirus disease 2019 (COVID-19) was first identified in
Wuhan, China on December 2019 in patients presenting with atypical pneumonia.
Although 'city-lockdown' policy reduced the spatial spreading of the COVID-19,
the city-level outbreaks within each city remain a major concern to be addressed.
The local or regional level disease control mainly depends on individuals
self-administered infection prevention actions. The contradiction between choice
of taking infection prevention actions or not makes the elimination difficult
under a voluntary acting scheme, and represents a clash between the optimal
choice of action for the individual interest and group interests. METHODS: We
develop a compartmental epidemic model based on the classic
susceptible-exposed-infectious-recovered model and use this to fit the data.
Behavioral imitation through a game theoretical decision-making process is
incorporated to study and project the dynamics of the COVID-19 outbreak in Wuhan,
China. By varying the key model parameters, we explore the probable course of the
outbreak in terms of size and timing under several public interventions in
improving public awareness and sensitivity to the infection risk as well as their
potential impact. RESULTS: We estimate the basic reproduction number, R (0), to
be 2.5 (95% CI: 2.4-2.7). Under the current most realistic setting, we estimate
the peak size at 0.28 (95% CI: 0.24-0.32) infections per 1,000 population. In
Wuhan, the final size of the outbreak is likely to infect 1.35% (95% CI:
1.00-2.12%) of the population. The outbreak will be most likely to peak in the
first half of February and drop to daily incidences lower than 10 in June 2020.
Increasing sensitivity to take infection prevention actions and the effectiveness
of infection prevention measures are likely to mitigate the COVID-19 outbreak in
Wuhan. CONCLUSIONS: Through an imitating social learning process,
individual-level behavioral change on taking infection prevention actions have
the potentials to significantly reduce the COVID-19 outbreak in terms of size and
timing at city-level. Timely and substantially resources and supports for
improving the willingness-to-act and conducts of self-administered infection
prevention actions are recommended to reduce to the COVID-19 associated risks.