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10.1016/j.immuni.2020.04.005 http://scihub22266oqcxt.onion/10.1016/j.immuni.2020.04.005 C7207120!7207120 !32392463     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32392463 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunity 2020 ; 52 (6 ): 1039-1056.e9 Nephropedia Template TP {{tp|p=32392463 |t=2020. Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection |pdf=|usr=}}{{32392463 }} gab.com Text Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=32392463 #FOAvip The phenotypic and functional dichotomy between IRF8(+) type 1 and IRF4(+) type 2 conventional dendritic cells (cDC1s and cDC2s, respectively) is well accepted; it is unknown how robust this dichotomy is under inflammatory conditions, when additionally monocyte-derived cells (MCs) become competent antigen-presenting cells (APCs). Using single-cell technologies in models of respiratory viral infection, we found that lung cDC2s acquired expression of the Fc receptor CD64 shared with MCs and of IRF8 shared with cDC1s. These inflammatory cDC2s (inf-cDC2s) were superior in inducing CD4(+) T helper (Th) cell polarization while simultaneously presenting antigen to CD8(+) T cells. When carefully separated from inf-cDC2s, MCs lacked APC function. Inf-cDC2s matured in response to cell-intrinsic Toll-like receptor and type 1 interferon receptor signaling, upregulated an IRF8-dependent maturation module, and acquired antigens via convalescent serum and Fc receptors. Because hybrid inf-cDC2s are easily confused with monocyte-derived cells, their existence could explain why APC functions have been attributed to MCs. Twit Text FOAVip Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=32392463 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32392463 #FOAvip English Wikipedia <ref>{{Cite pmid|32392463 }}</ref> Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection #MMPMID32392463 Bosteels C ; Neyt K ; Vanheerswynghels M ; van Helden MJ ; Sichien D ; Debeuf N ; De Prijck S ; Bosteels V ; Vandamme N ; Martens L ; Saeys Y ; Louagie E ; Lesage M ; Williams DL ; Tang SC ; Mayer JU ; Ronchese F ; Scott CL ; Hammad H ; Guilliams M ; Lambrecht BN Immunity 2020[Jun]; 52 (6 ): 1039-1056.e9 PMID32392463 show ga The phenotypic and functional dichotomy between IRF8(+) type 1 and IRF4(+) type 2 conventional dendritic cells (cDC1s and cDC2s, respectively) is well accepted; it is unknown how robust this dichotomy is under inflammatory conditions, when additionally monocyte-derived cells (MCs) become competent antigen-presenting cells (APCs). Using single-cell technologies in models of respiratory viral infection, we found that lung cDC2s acquired expression of the Fc receptor CD64 shared with MCs and of IRF8 shared with cDC1s. These inflammatory cDC2s (inf-cDC2s) were superior in inducing CD4(+) T helper (Th) cell polarization while simultaneously presenting antigen to CD8(+) T cells. When carefully separated from inf-cDC2s, MCs lacked APC function. Inf-cDC2s matured in response to cell-intrinsic Toll-like receptor and type 1 interferon receptor signaling, upregulated an IRF8-dependent maturation module, and acquired antigens via convalescent serum and Fc receptors. Because hybrid inf-cDC2s are easily confused with monocyte-derived cells, their existence could explain why APC functions have been attributed to MCs. |*Immunity [MESH] |Antigen Presentation [MESH] |Biomarkers [MESH] |Cell Plasticity/*immunology [MESH] |Dendritic Cells/*immunology/*metabolism [MESH] |Disease Susceptibility [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation [MESH] |Gene Regulatory Networks [MESH] |Immunophenotyping [MESH] |Interferon Type I/metabolism [MESH] |Macrophages/*immunology/*metabolism [MESH] |Monocytes/immunology/metabolism [MESH] |Organ Specificity/immunology [MESH] |Receptors, Fc/metabolism [MESH] |Respirovirus Infections/*etiology/metabolism [MESH] |T-Lymphocyte Subsets/immunology/metabolism [MESH] |Transcription Factors [MESH]Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to (epmc).pdf DeepDyve Pubget Overpricing