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Low dose radiation therapy as a potential life saving treatment for
COVID-19-induced acute respiratory distress syndrome (ARDS)
#MMPMID32437820
Dhawan G
; Kapoor R
; Dhawan R
; Singh R
; Monga B
; Giordano J
; Calabrese EJ
Radiother Oncol
2020[Jun]; 147
(?): 212-216
PMID32437820
show ga
The new coronavirus COVID-19 disease caused by SARS-CoV-2 was declared a global
public health emergency by WHO on Jan 30, 2020. Despite massive efforts from
various governmental, health and medical organizations, the disease continues to
spread globally with increasing fatality rates. Several experimental drugs have
been approved by FDA with unknown efficacy and potential adverse effects. The
exponentially spreading pandemic of COVID-19 deserves prime public health
attention to evaluate yet unexplored arenas of management. We opine that one of
these treatment options is low dose radiation therapy for severe and most
critical cases. There is evidence in literature that low dose radiation induces
an anti-inflammatory phenotype that can potentially afford therapeutic benefit
against COVID-19-related complications that are associated with significant
morbidity and mortality. Herein, we review the effects and putative mechanisms of
low dose radiation that may be viable, useful and of value in counter-acting the
acute inflammatory state induced by critical stage COVID-19.
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