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Influencia de la infección SARS-CoV-2 sobre enfermedades neurodegenerativas y
neuropsiquiátricas: ¿una pandemia demorada?
#MMPMID32364119
Serrano-Castro PJ
; Estivill-Torrús G
; Cabezudo-García P
; Reyes-Bueno JA
; Ciano Petersen N
; Aguilar-Castillo MJ
; Suárez-Pérez J
; Jiménez-Hernández MD
; Moya-Molina MÁ
; Oliver-Martos B
; Arrabal-Gómez C
; Rodríguez de Fonseca F
Neurologia (Engl Ed)
2020[May]; 35
(4
): 245-251
PMID32364119
show ga
INTRODUCTION: SARS-CoV-2 was first detected in December 2019 in the Chinese city
of Wuhan and has since spread across the world. At present, the virus has
infected over 1.7 million people and caused over 100 000 deaths worldwide.
Research is currently focused on understanding the acute infection and developing
effective treatment strategies. In view of the magnitude of the epidemic, we
conducted a speculative review of possible medium- and long-term neurological
consequences of SARS-CoV-2 infection, with particular emphasis on
neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin,
based on the available evidence on neurological symptoms of acute SARS-CoV-2
infection. DEVELOPMENT: We systematically reviewed the available evidence about
the pathogenic mechanisms of SARS-CoV-2 infection, the immediate and lasting
effects of the cytokine storm on the central nervous system, and the consequences
of neuroinflammation for the central nervous system. CONCLUSIONS: SARS-CoV-2 is a
neuroinvasive virus capable of triggering a cytokine storm, with persistent
effects in specific populations. Although our hypothesis is highly speculative,
the impact of SARS-CoV-2 infection on the onset and progression of
neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin
should be regarded as the potential cause of a delayed pandemic that may have a
major public health impact in the medium to long term. Cognitive and
neuropsychological function should be closely monitored in COVID-19 survivors.
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