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10.1093/nsr/nwaa086 http://scihub22266oqcxt.onion/10.1093/nsr/nwaa086 C7197563!7197563!34676128     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Natl+Sci+Rev 2020 ; 7 (7): 1157-68 Nephropedia Template TP {{tp|p=34676128|t=2020. Plasma metabolomic and lipidomic alterations associated with COVID-19 |pdf=|usr=}}{{34676128}} gab.com Text Plasma metabolomic and lipidomic alterations associated with COVID-19 JO: Natl Sci Rev http://www.kidney.de/pget.php?&tw=1&pmid=34676128 #FOAvip The pandemic of the coronavirus disease 2019 (COVID-19) has become a global public health crisis. The symptoms of COVID-19 range from mild to severe, but the physiological changes associated with COVID-19 are barely understood. In this study, we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms. We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients, indicating that the development of COVID-19 affected their whole-body metabolism. In particular, malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction, respectively. It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms. And, more importantly, guanosine monophosphate (GMP), which is mediated not only by GMP synthase but also by CD39 and CD73, is significantly changed between healthy subjects and patients with COVID-19, as well as between the mild and fatal cases. In addition, dyslipidemia was observed in patients with COVID-19. Overall, the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19. This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets, as well as an important resource for further studies of the pathogenesis of COVID-19. Twit Text FOAVip Plasma metabolomic and lipidomic alterations associated with COVID-19 ????Natl Sci Rev http://www.kidney.de/pget.php?&tw=1&pmid=34676128 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34676128 #FOAvip English Wikipedia <ref>{{Cite pmid|34676128}}</ref> Plasma metabolomic and lipidomic alterations associated with COVID-19 #MMPMID34676128 Wu D; Shu T; Yang X; Song JX; Zhang M; Yao C; Liu W; Huang M; Yu Y; Yang Q; Zhu T; Xu J; Mu J; Wang Y; Wang H; Tang T; Ren Y; Wu Y; Lin SH; Qiu Y; Zhang DY; Shang Y; Zhou X Natl Sci Rev 2020[Jul]; 7 (7): 1157-68 PMID34676128show ga The pandemic of the coronavirus disease 2019 (COVID-19) has become a global public health crisis. The symptoms of COVID-19 range from mild to severe, but the physiological changes associated with COVID-19 are barely understood. In this study, we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms. We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients, indicating that the development of COVID-19 affected their whole-body metabolism. In particular, malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction, respectively. It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms. And, more importantly, guanosine monophosphate (GMP), which is mediated not only by GMP synthase but also by CD39 and CD73, is significantly changed between healthy subjects and patients with COVID-19, as well as between the mild and fatal cases. In addition, dyslipidemia was observed in patients with COVID-19. Overall, the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19. This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets, as well as an important resource for further studies of the pathogenesis of COVID-19. äPlasma metabolomic and lipidomic alterations associated with COVID-19 (epmc).pdf DeepDyve Pubget Overpricing