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2020 ; 49
(6
): 848-852
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
A review of cardiac manifestations and predictors of outcome in patients with
COVID - 19
#MMPMID32593418
Mishra AK
; Sahu KK
; George AA
; Lal A
Heart Lung
2020[Nov]; 49
(6
): 848-852
PMID32593418
show ga
Coronavirus disease (COVID-19) pandemic has so far involved 184 countries and
more than 2.79 million patients worldwide. Over the past three months, it has
attributed to more than 196,000 deaths, with more than 50,000 deaths in the
United States alone. Pulmonary manifestations are predominant and have been well
identified. Cardiac involvement is also common. Acute cardiac injury, the most
common cardiac manifestation of this disease can be seen in patients even without
prior cardiac comorbidities. Established cardiovascular risk factors such as
diabetes mellitus, hypertension, and coronary artery disease predispose to
cardiac injury, the severity of illness and mortality. Non-ischemic myocardial
injury secondary to cytokine storm is thought to be the predominant mechanism of
acute cardiac injury associated with COVID-19. Multiple mechanisms and processes
contribute to cardiac injury resulting in a poor outcome. Some of these are not
clearly understood. Clinical and diagnostic details of cardiovascular involvement
in these patients are mostly limited to biochemical markers. Multiple therapeutic
agents have been tried with questionable efficacy and without clinical evidence.
Interactions of comorbidities, cardiovascular drugs, the cardiac effect of
therapeutic agents on the illness continue to be under investigation. With an
increasing number of patients, newer promising therapies, and ongoing clinical
trials, the exact mechanisms and extent to which these risk factors contribute to
outcomes will be clearer in the future.