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10.1016/j.ijid.2020.04.017

http://scihub22266oqcxt.onion/10.1016/j.ijid.2020.04.017
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suck abstract from ncbi


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pmid32283281
      Int+J+Infect+Dis 2020 ; 95 (ä): 74-83
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  • Pneumonia in children admitted to the national referral hospital in Bhutan: A prospective cohort study #MMPMID32283281
  • Jullien S ; Pradhan D ; Tshering T ; Sharma R ; Dema K ; Garcia-Garcia S ; Ribó JL ; Muñoz-Almagro C ; Bassat Q
  • Int J Infect Dis 2020[Jun]; 95 (ä): 74-83 PMID32283281 show ga
  • OBJECTIVES: The study aim was to describe the etiological profile and clinical characteristics of pneumonia among children hospitalized in Thimphu, Bhutan. METHODS: This prospective study enrolled children aged 2-59 months admitted to the Jigme Dorji Wangchuck National Referral Hospital with World Health Organization (WHO)-defined clinical pneumonia. Demographic and clinico-radiological data were collected through questionnaires, physical examination, and chest radiography. Blood samples and nasopharyngeal washing were collected for microbiological analysis including culture and molecular methods. RESULTS: From July 2017 to June 2018, 189 children were enrolled, of which 53.4% were infants. Pneumonia-related admissions were less frequent over the winter. Chest radiographies were obtained in 149 children; endpoints included pneumonia in 39 cases (26.2%), other infiltrates in 31 (20.8%), and were normal in 79 children (53.0%). Non-contaminated bacterial growth was detected in 8/152 (5.3%) blood cultures, with only two cases of Streptococcus pneumoniae. Viral detection in upper respiratory secretions was common, with at least one virus detected in 103/115 (89.6%). The three most-commonly isolated viruses were respiratory syncytial virus (52/115; 45.2%), rhinovirus (42/115; 36.5%), and human parainfluenza virus (19/115; 16.5%). A third of patients with viral infections showed mixed infections. Case fatality rate was 3.2% (6/189). CONCLUSION: Respiratory viral infections predominated among this cohort of WHO-defined clinical pneumonia cases, whereas bacterial aetiologies were uncommon, highlighting the epidemiologic transition that Bhutan seems to have reached.
  • |Bacteria/isolation & purification [MESH]
  • |Bhutan/epidemiology [MESH]
  • |Child, Preschool [MESH]
  • |Cohort Studies [MESH]
  • |Coinfection/epidemiology [MESH]
  • |Demography [MESH]
  • |Female [MESH]
  • |Hospitalization [MESH]
  • |Humans [MESH]
  • |Infant [MESH]
  • |Male [MESH]
  • |Pneumonia, Bacterial/*diagnosis/diagnostic imaging/*epidemiology/microbiology [MESH]
  • |Pneumonia, Viral/*diagnosis/diagnostic imaging/*epidemiology/virology [MESH]
  • |Pneumonia/epidemiology/mortality [MESH]
  • |Prospective Studies [MESH]
  • |Respiratory Syncytial Virus, Human/isolation & purification [MESH]
  • |Respirovirus/isolation & purification [MESH]
  • |Rhinovirus/isolation & purification [MESH]


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