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10.1186/s12864-020-6745-3 http://scihub22266oqcxt.onion/10.1186/s12864-020-6745-3 C7190201!7190201!32349669     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Genomics 2020 ; 21 (ä): ä Nephropedia Template TP {{tp|p=32349669|t=2020. Genome-wide analysis on the maize genome reveals weak selection on synonymous mutations |pdf=|usr=}}{{32349669}} gab.com Text Genome-wide analysis on the maize genome reveals weak selection on synonymous mutations JO: BMC Genomics http://www.kidney.de/pget.php?&tw=1&pmid=32349669 #FOAvip Background: Synonymous mutations are able to change the tAI (tRNA adaptation index) of a codon and consequently affect the local translation rate. Intuitively, one may hypothesize that those synonymous mutations which increase the tAI values are favored by natural selection. Results: We use the maize (Zea mays) genome to test our assumption. The first supporting evidence is that the tAI-increasing synonymous mutations have higher fixed-to-polymorphic ratios than the tAI-decreasing ones. Next, the DAF (derived allele frequency) or MAF (minor allele frequency) of the former is significantly higher than the latter. Moreover, similar results are obtained when we investigate CAI (codon adaptation index) instead of tAI. Conclusion: The synonymous mutations in the maize genome are not strictly neutral. The tAI-increasing mutations are positively selected while those tAI-decreasing ones undergo purifying selection. This selection force might be weak but should not be automatically ignored. Twit Text FOAVip Genome-wide analysis on the maize genome reveals weak selection on synonymous mutations ????BMC Genomics http://www.kidney.de/pget.php?&tw=1&pmid=32349669 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32349669 #FOAvip English Wikipedia <ref>{{Cite pmid|32349669}}</ref> Genome-wide analysis on the maize genome reveals weak selection on synonymous mutations #MMPMID32349669 Chu D; Wei L BMC Genomics 2020[]; 21 (ä): ä PMID32349669show ga Background: Synonymous mutations are able to change the tAI (tRNA adaptation index) of a codon and consequently affect the local translation rate. Intuitively, one may hypothesize that those synonymous mutations which increase the tAI values are favored by natural selection. Results: We use the maize (Zea mays) genome to test our assumption. The first supporting evidence is that the tAI-increasing synonymous mutations have higher fixed-to-polymorphic ratios than the tAI-decreasing ones. Next, the DAF (derived allele frequency) or MAF (minor allele frequency) of the former is significantly higher than the latter. Moreover, similar results are obtained when we investigate CAI (codon adaptation index) instead of tAI. Conclusion: The synonymous mutations in the maize genome are not strictly neutral. The tAI-increasing mutations are positively selected while those tAI-decreasing ones undergo purifying selection. This selection force might be weak but should not be automatically ignored. äGenome-wide analysis on the maize genome reveals weak selection on syn(epmc).pdf DeepDyve Pubget Overpricing