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Hantoushzadeh S; Shamshirsaz AA; Aleyasin A; Seferovic MD; Aski SK; Arian SE; Pooransari P; Ghotbizadeh F; Aalipour S; Soleimani Z; Naemi M; Molaei B; Ahangari R; Salehi M; Oskoei AD; Pirozan P; Darkhaneh RF; Laki MG; Farani AK; Atrak S; Miri MM; Kouchek M; Shojaei S; Hadavand F; Keikha F; Hosseini MS; Borna S; Ariana S; Shariat M; Fatemi A; Nouri B; Nekooghadam SM; Aagaard K
Am J Obstet Gynecol 2020[Jul]; 223 (1): 109.e1-109.e16 PMID32360108show ga
Background: Despite 2.5 million infections and 169,000 deaths worldwide (as of April 20, 2020), no maternal deaths and only a few pregnant women afflicted with severe respiratory morbidity have been reported to be related to COVID-19 disease. Given the disproportionate burden of severe and fatal respiratory disease previously documented among pregnant women following other coronavirus-related outbreaks (SARS-CoV in 2003 and MERS-CoV in 2012) and influenza pandemics over the last century, the absence of reported maternal morbidity and mortality with COVID-19 disease is unexpected. Objective: To describe maternal and perinatal outcomes and death in a case series of pregnant women with COVID-19 disease. Study Design: We describe here a multiinstitution adjudicated case series from Iran that includes 9 pregnant women diagnosed with severe COVID-19 disease in their second or third trimester. All 9 pregnant women received a diagnosis of SARS-CoV-2 infection by reverse transcription polymerase chain reaction nucleic acid testing. Outcomes of these women were compared with their familial/household members with contact to the affected patient on or after their symptom onset. All data were reported at death or after a minimum of 14 days from date of admission with COVID-19 disease. Results: Among 9 pregnant women with severe COVID-19 disease, at the time of reporting, 7 of 9 died, 1 of 9 remains critically ill and ventilator dependent, and 1 of 9 recovered after prolonged hospitalization. We obtained self-verified familial/household cohort data in all 9 cases, and in each and every instance, maternal outcomes were more severe compared with outcomes of other high- and low-risk familial/household members (n=33 members for comparison). Conclusion: We report herein maternal deaths owing to COVID-19 disease. Until rigorously collected surveillance data emerge, it is prudent to be aware of the potential for maternal death among pregnant women diagnosed as having COVID-19 disease in their second or third trimester.
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Am+J+Obstet+Gynecol 2020 ; 223 (1): 109.e1-109.e16
