Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\C7187744
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 ä-/-ä 2020 ; 2
(SI
): 3-10
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Diagnosis of COVID-19: Considerations, Controversies and Challenges in South
Africa
#MMPMIDC7187744
Dheda K
; Jaumdally S
; Davids M
; Chang JW
; Gina P
; Pooran A
; Makambwa E
; Esmail A
; Vardas E
; Preiser W
ä-/-ä 2020[Apr]; 2
(SI
): 3-10
PMIDC7187744
show ga
Coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome
coronavirus 2 is a global pandemic that has resulted in over 1.5 million
confirmed cases and close to 100,000 deaths. In the majority of symptomatic cases
COVID-19 results in a mild disease predominantly characterised by upper
respiratory tract symptoms. Reverse transcription polymerase chain reaction
(RT-PCR), using a nasopharyngeal sample, is the mainstay of diagnosis, but there
is an ~30% false negative rate early in the disease and in patients with mild
disease. RT-PCR positivity can persist for several days after a resolution of
symptoms. IgM and IgG antibody responses become positive several days after the
onset of symptoms, and robust antibody responses are detectable in the second
week of illness. Antibody-based immunoassays have a limited role in the diagnosis
of early symptomatic disease. However, their incremental benefit over RT-PCR in
the first 2 weeks of illness is currently being clarified in ongoing studies.
Such assays may be useful for surveillance purposes. However, their role in
potentially selecting individuals that may benefit from vaccination, or as a
biomarker identifying persons that could be redeployed into essential employment
roles are being investigated. Rapid antibody-based immunoassays that detect viral
antigen in nasopharyngeal samples are being developed and evaluated.