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2020 ; 53
(ä): 53-62
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English Wikipedia
The protective and pathogenic roles of CXCL17 in human health and disease:
Potential in respiratory medicine
#MMPMID32345516
Choreño-Parra JA
; Thirunavukkarasu S
; Zúñiga J
; Khader SA
Cytokine Growth Factor Rev
2020[Jun]; 53
(ä): 53-62
PMID32345516
show ga
C-X-C motif chemokine 17 (CXCL-17) is a novel chemokine that plays a functional
role maintaining homeostasis at distinct mucosal barriers, including regulation
of myeloid-cell recruitment, angiogenesis, and control of microorganisms.
Particularly, CXCL17 is produced along the epithelium of the airways both at
steady state and under inflammatory conditions. While increased CXCL17 expression
is associated with disease progression in pulmonary fibrosis, asthma, and
lung/hepatic cancer, it is thought to play a protective role in pancreatic
cancer, autoimmune encephalomyelitis and viral infections. Thus, there is
emerging evidence pointing to both a harmful and protective role for CXCL17 in
human health and disease, with therapeutic potential for translational
applications. In this review, we provide an overview of the discovery,
characteristics and functions of CXCL17 emphasizing its clinical potential in
respiratory disorders.