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Pathogenesis: Infection and the Spread of Viruses in the Body
#MMPMIDC7173411
FENNER F
; BACHMANN PA
; GIBBS EPJ
; MURPHY FA
; STUDDERT MJ
; WHITE DO
Veterinary Virology
1987[]; ? (?): 133-52
PMIDC7173411
show ga
At the molecular and cellular levels, viruses behave quite differently from
bacteria and protozoa but to some extent, this distinction disappears when
viruses are considered at the levels of the whole animal and the population.
Viruses, like other infectious agents, enter the animal body through one of its
surfaces. They then spread either locally on one of the body surfaces or through
lymphatic and blood vessels to produce systemic infection. To infect its host, a
virus first attaches to and infects cells of one of the body surfaces: the skin,
the mucosa of the digestive, respiratory, or urogenital tract, or the
conjunctiva. Parenteral injection, either by needle or by the bite of an
arthropod or vertebrate, bypasses the body surfaces. A lesion may be produced at
the site of entry, although invasion may occur without the development of any
local evidence of infection. The infection may remain localized in the skin,
respiratory tract, or digestive tract or it may spread through the animal via the
lymphatics, blood vessels, or nerves.