Effective Use of Angiotensin II in Coronavirus Disease 19-Associated Mixed Shock
State: A Case Report
#MMPMID32784326
Bobeck KA
; Holtzclaw AW
; Brown TE
; Clark PA
A A Pract
2020[Apr]; 14
(6
): e01221
PMID32784326
show ga
The rapid spread of Coronavirus Disease 2019 (COVID-19) has sparked a search for
effective therapies. The discovery that the virus binds the
angiotensin-converting enzyme 2 (ACE2) receptor has led to investigation of the
renin-angiotensin system for possible therapeutic targets. We present a case of
an elderly woman with multiple comorbidities who developed severe acute
respiratory distress syndrome (ARDS), a cardiomyopathy, and vasodilatory shock
secondary to COVID-19 and was treated with exogenous angiotensin II. She rapidly
demonstrated significant hemodynamic improvement without noted adverse effects.
Thus, we propose further investigation into possible benefits of angiotensin II
in shock secondary to COVID-19.
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