| 10.1002/wrna.12
http://scihub22266oqcxt.onion/10.1002/wrna.12
C7169711!7169711!21935894 free free free
| Wiley+Interdiscip+Rev+RNA 2010 ; 1 (2): 341-50 Nephropedia Template TP
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Delivery of RNAi mediators #MMPMID21935894Ford LP; Toloue MMWiley Interdiscip Rev RNA 2010[Sep]; 1 (2): 341-50 PMID21935894show ga
Delivering polynucleotides into animals has been a major challenge facing their success as therapeutic agents. Given the matured understanding of antibody?mediated delivery techniques, it is possible to rationally design delivery vehicles that circulate in the blood stream and are specifically delivered into target organs. If the targeting moiety is designed to contain the cargo of an RNAi mediator without impacting its paratope, directed delivery can be achieved. In this article, we review the state of art in delivery technology for RNA mediators and address how this technique could soon be used to enhance the efficacy of the numerous small RNA therapeutic programs currently under evaluation. Copyright © 2010 John Wiley & Sons, Ltd.This article is categorized under: 1Regulatory RNAs/RNAi/Riboswitches > RNAi: Mechanisms of Action2RNA Methods > RNA Analyses in Cells3RNA in Disease and Development > RNA in Diseaseä
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