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10.1111/1348-0421.12230 http://scihub22266oqcxt.onion/10.1111/1348-0421.12230 C7168458!7168458!25643977     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microbiol+Immunol 2015 ; 59 (3): 129-41 Nephropedia Template TP {{tp|p=25643977|t=2015. Assessment of flavaglines as potential chikungunya virus entry inhibitors |pdf=|usr=}}{{25643977}} gab.com Text Assessment of flavaglines as potential chikungunya virus entry inhibitors JO: Microbiol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25643977 #FOAvip Chikungunya virus (CHIKV) is a re?emerging mosquito?borne alphavirus that recently caused large epidemics in islands in, and countries around, the Indian Ocean. There is currently no specific drug for therapeutic treatment or for use as a prophylactic agent against infection and no commercially available vaccine. Prohibitin has been identified as a receptor protein used by chikungunya virus to enter mammalian cells. Recently, synthetic sulfonyl amidines and flavaglines (FLs), a class of naturally occurring plant compounds with potent anti?cancer and cytoprotective and neuroprotective activities, have been shown to interact directly with prohibitin. This study therefore sought to determine whether three prohibitin ligands (sulfonyl amidine 1?m and the flavaglines FL3 and FL23) were able to inhibit CHIKV infection of mammalian Hek293T/17 cells. All three compounds inhibited infection and reduced virus production when cells were treated before infection but not when added after infection. Pretreatment of cells for only 15?minutes prior to infection followed by washing out of the compound resulted in significant inhibition of entry and virus production. These results suggest that further investigation of prohibitin ligands as potential Chikungunya virus entry inhibitors is warranted. Twit Text FOAVip Assessment of flavaglines as potential chikungunya virus entry inhibitors ????Microbiol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25643977 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25643977 #FOAvip English Wikipedia <ref>{{Cite pmid|25643977}}</ref> Assessment of flavaglines as potential chikungunya virus entry inhibitors #MMPMID25643977 Wintachai P; Thuaud F; Basmadjian C; Roytrakul S; Ubol S; Désaubry L; Smith DR Microbiol Immunol 2015[Mar]; 59 (3): 129-41 PMID25643977show ga Chikungunya virus (CHIKV) is a re?emerging mosquito?borne alphavirus that recently caused large epidemics in islands in, and countries around, the Indian Ocean. There is currently no specific drug for therapeutic treatment or for use as a prophylactic agent against infection and no commercially available vaccine. Prohibitin has been identified as a receptor protein used by chikungunya virus to enter mammalian cells. Recently, synthetic sulfonyl amidines and flavaglines (FLs), a class of naturally occurring plant compounds with potent anti?cancer and cytoprotective and neuroprotective activities, have been shown to interact directly with prohibitin. This study therefore sought to determine whether three prohibitin ligands (sulfonyl amidine 1?m and the flavaglines FL3 and FL23) were able to inhibit CHIKV infection of mammalian Hek293T/17 cells. All three compounds inhibited infection and reduced virus production when cells were treated before infection but not when added after infection. Pretreatment of cells for only 15?minutes prior to infection followed by washing out of the compound resulted in significant inhibition of entry and virus production. These results suggest that further investigation of prohibitin ligands as potential Chikungunya virus entry inhibitors is warranted. äAssessment of flavaglines as potential chikungunya virus entry inhibit(epmc).pdf DeepDyve Pubget Overpricing