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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Microbiol+Immunol
2013 ; 57
(8
): 553-60
Nephropedia Template TP
gab.com Text
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English Wikipedia
Outbreak of acute respiratory disease caused by human adenovirus type 7 in a
military training camp in Shaanxi, China
#MMPMID23734976
Yu P
; Ma C
; Nawaz M
; Han L
; Zhang J
; Du Q
; Zhang L
; Feng Q
; Wang J
; Xu J
Microbiol Immunol
2013[Aug]; 57
(8
): 553-60
PMID23734976
show ga
Outbreaks of ARD associated with HAdV have been reported in military populations
in many countries. Here, we report an ARD outbreak caused by HAdV-7 in a military
training camp in Shaanxi Province, China, from February to March of 2012.
Epidemic data and samples from the patients were collected, and viral nucleotides
from samples and viral isolations were detected and sequenced. IgG and IgA
antibodies against HAdV, and the neutralization antibodies against the viral
strain isolated in this outbreak, were detected. Epidemiological study showed
that all personnel affected were males with an average age of 19.1 years. Two
peaks appeared on the epicurve and there was an 8-day interval between peaks.
Laboratory results of viral nucleotide detection carried out with clinical
specimens were positive for HAdV (83.33%, 15/18). Further study through serum
antibody assay, virus isolation and phylogenetic analysis showed that HAdV-7 was
the etiological agent responsible for the outbreak. IgA antibody began to appear
on the 4th day after the onset and showed 100% positivity on the 8th day. The
virus strain in the present outbreak was highly similar to the virus isolated in
Hanzhong Shaanxi in 2009. We conclude that HAdV-7 was the pathogen corresponding
to the outbreak, and this is the first report of an ARD outbreak caused by HAdV-7
in military persons in China. Vaccine development, as well as enhanced
epidemiological and virological surveillance of HAdV infections in China should
be emphasized.