Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30070073
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Pediatr+Blood+Cancer
2018 ; 65
(11
): e27344
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Is an infectious trigger always required for primary hemophagocytic
lymphohistiocytosis? Lessons from in utero and neonatal disease
#MMPMID30070073
Heeg M
; Ammann S
; Klemann C
; Panning M
; Falcone V
; Hengel H
; Lehmberg K
; Zur Stadt U
; Wustrau K
; Janka G
; Ehl S
Pediatr Blood Cancer
2018[Nov]; 65
(11
): e27344
PMID30070073
show ga
In this report, we evaluate the hypothesis that hemophagocytic
lymphohistiocytosis in patients with defects of lymphocyte cytotoxicity is
usually triggered by infections. We show that in the majority of patients,
extensive virus PCR panels performed in addition to routine microbiological
investigations remain negative and summarize 25 patients with onset of
hemophagocytic lymphohistiocytosis in utero or within the first 10 days of life,
in none of which an associated bacterial or viral infection was reported. These
observations, even though preliminary, invite to consider a key role of
lymphocyte cytotoxicity in controlling T-cell homeostasis also in the absence of
apparent infectious stimuli.