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10.1002/pmic.201200225 http://scihub22266oqcxt.onion/10.1002/pmic.201200225 C7168038!7168038 !22936401     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\22936401 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proteomics 2012 ; 12 (21 ): 3193-205 Nephropedia Template TP {{tp|p=22936401 |t=2012. Correlation between TGF-?1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease |pdf=|usr=}}{{22936401 }} gab.com Text Correlation between TGF- 1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease JO: Proteomics http://www.kidney.de/pget.php?&tw=1&pmid=22936401 #FOAvip Severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) papain-like protease (PLpro), a deubiquitinating enzyme, demonstrates inactivation of interferon (IFN) regulatory factor 3 and NF-?B, reduction of IFN induction, and suppression of type I IFN signaling pathway. This study investigates cytokine expression and proteomic change induced by SARS-CoV PLpro in human promonocyte cells. PLpro significantly increased TGF-?1 mRNA expression (greater than fourfold) and protein production (greater than threefold). Proteomic analysis, Western blot, and quantitative real-time PCR assays indicated PLpro upregulating TGF-?1-associated genes: HSP27, protein disulfide isomerase A3 precursor, glial fibrillary acidic protein, vimentin, retinal dehydrogenase 2, and glutathione transferase omega-1. PLpro-activated ubiquitin proteasome pathway via upregulation of ubiquitin-conjugating enzyme E2-25k and proteasome subunit alpha type 5. Proteasome inhibitor MG-132 significantly reduced expression of TGF-?1 and vimentin. PLpro upregulated HSP27, linking with activation of p38 MAPK and ERK1/2 signaling. Treatment with SB203580 and U0126 reduced PLpro-induced expression of TGF-?1, vimentin, and type I collagen. Results point to SARS-CoV PLpro triggering TGF-?1 production via ubiquitin proteasome, p38 MAPK, and ERK1/2-mediated signaling. Twit Text FOAVip Correlation between TGF- 1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease ????Proteomics http://www.kidney.de/pget.php?&tw=1&pmid=22936401 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22936401 #FOAvip English Wikipedia <ref>{{Cite pmid|22936401 }}</ref> Correlation between TGF-?1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease #MMPMID22936401 Li SW ; Yang TC ; Wan L ; Lin YJ ; Tsai FJ ; Lai CC ; Lin CW Proteomics 2012[Nov]; 12 (21 ): 3193-205 PMID22936401 show ga Severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) papain-like protease (PLpro), a deubiquitinating enzyme, demonstrates inactivation of interferon (IFN) regulatory factor 3 and NF-?B, reduction of IFN induction, and suppression of type I IFN signaling pathway. This study investigates cytokine expression and proteomic change induced by SARS-CoV PLpro in human promonocyte cells. PLpro significantly increased TGF-?1 mRNA expression (greater than fourfold) and protein production (greater than threefold). Proteomic analysis, Western blot, and quantitative real-time PCR assays indicated PLpro upregulating TGF-?1-associated genes: HSP27, protein disulfide isomerase A3 precursor, glial fibrillary acidic protein, vimentin, retinal dehydrogenase 2, and glutathione transferase omega-1. PLpro-activated ubiquitin proteasome pathway via upregulation of ubiquitin-conjugating enzyme E2-25k and proteasome subunit alpha type 5. Proteasome inhibitor MG-132 significantly reduced expression of TGF-?1 and vimentin. PLpro upregulated HSP27, linking with activation of p38 MAPK and ERK1/2 signaling. Treatment with SB203580 and U0126 reduced PLpro-induced expression of TGF-?1, vimentin, and type I collagen. Results point to SARS-CoV PLpro triggering TGF-?1 production via ubiquitin proteasome, p38 MAPK, and ERK1/2-mediated signaling. |Animals [MESH] |Cell Line [MESH] |Chi-Square Distribution [MESH] |Coronavirus 3C Proteases [MESH] |Cysteine Endopeptidases/*pharmacology [MESH] |Electrophoresis, Gel, Two-Dimensional [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH] |Leupeptins/pharmacology [MESH] |Mice [MESH] |Monocyte-Macrophage Precursor Cells/drug effects [MESH] |Proteasome Endopeptidase Complex/drug effects/metabolism [MESH] |Proteome/*drug effects [MESH] |Proteomics/methods [MESH] |RNA, Messenger/analysis/genetics [MESH] |Transforming Growth Factor beta1/*biosynthesis/genetics/metabolism [MESH] |Ubiquitin/metabolism [MESH] |Vimentin/metabolism [MESH]Correlation between TGF-?1 expression and proteomic profiling induced (epmc).pdf DeepDyve Pubget Overpricing