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10.1002/ppul.23931 http://scihub22266oqcxt.onion/10.1002/ppul.23931 C7167837!7167837!29265639     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pediatr+Pulmonol 2018 ; 53 (2): 224-32 Nephropedia Template TP {{tp|p=29265639|t=2018. Defining lower airway bacterial infection in children with chronic endobronchial disorders |pdf=|usr=}}{{29265639}} gab.com Text Defining lower airway bacterial infection in children with chronic endobronchial disorders JO: Pediatr Pulmonol http://www.kidney.de/pget.php?&tw=1&pmid=29265639 #FOAvip Background: Differentiating lower airway bacterial infection from possible upper airway contamination in children with endobronchial disorders undergoing bronchoalveolar lavage (BAL) is important for guiding management. A diagnostic bacterial load threshold based on inflammatory markers has been determined to differentiate infection from upper airway contamination in infants with cystic fibrosis, but not for children with protracted bacterial bronchitis (PBB), chronic suppurative lung disease (CSLD), or bronchiectasis. Methods: BAL samples from children undergoing bronchoscopy underwent quantitative bacterial culture, cytologic examination, and respiratory virus testing; a subset also had interleukin?8 examined. Geometric means (GMs) of total cell counts (TCCs) and neutrophil counts were plotted by respiratory pathogen bacterial load. Logistic regression determined associations between age, sex, Indigenous status, antibiotic exposure, virus detection and bacterial load, and elevated TCCs (>400?×?103 cells/mL) and airway neutrophilia (neutrophils >15% BAL leukocytes). Results: From 2007 to 2016, 655 children with PBB, CSLD, or bronchiectasis were enrolled. In univariate analyses, Indigenous status and bacterial load ?105 colony?forming units (CFU)/mL were positively associated with high TCCs. Viruses and bacterial load ?104 CFU/mL were positively associated with neutrophilia; negative associations were seen for Indigenous status and macrolides. In children who had not received macrolide antibiotics, bacterial load was positively associated in multivariable analyses with high TCCs at ?104 CFU/mL and with neutrophilia at ?105 CFU/mL; GMs of TCCs and neutrophil counts were significantly elevated at 104 and 105 CFU/mL compared to negative cultures. Conclusions: Our findings support a BAL threshold ?104 CFU/mL to define lower airway infection in children with chronic endobronchial disorders. Twit Text FOAVip Defining lower airway bacterial infection in children with chronic endobronchial disorders ????Pediatr Pulmonol http://www.kidney.de/pget.php?&tw=1&pmid=29265639 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29265639 #FOAvip English Wikipedia <ref>{{Cite pmid|29265639}}</ref> Defining lower airway bacterial infection in children with chronic endobronchial disorders #MMPMID29265639 Hare KM; Pizzutto SJ; Chang AB; Smith?Vaughan HC; McCallum GB; Beissbarth J; Versteegh L; Grimwood K Pediatr Pulmonol 2018[Feb]; 53 (2): 224-32 PMID29265639show ga Background: Differentiating lower airway bacterial infection from possible upper airway contamination in children with endobronchial disorders undergoing bronchoalveolar lavage (BAL) is important for guiding management. A diagnostic bacterial load threshold based on inflammatory markers has been determined to differentiate infection from upper airway contamination in infants with cystic fibrosis, but not for children with protracted bacterial bronchitis (PBB), chronic suppurative lung disease (CSLD), or bronchiectasis. Methods: BAL samples from children undergoing bronchoscopy underwent quantitative bacterial culture, cytologic examination, and respiratory virus testing; a subset also had interleukin?8 examined. Geometric means (GMs) of total cell counts (TCCs) and neutrophil counts were plotted by respiratory pathogen bacterial load. Logistic regression determined associations between age, sex, Indigenous status, antibiotic exposure, virus detection and bacterial load, and elevated TCCs (>400?×?103 cells/mL) and airway neutrophilia (neutrophils >15% BAL leukocytes). Results: From 2007 to 2016, 655 children with PBB, CSLD, or bronchiectasis were enrolled. In univariate analyses, Indigenous status and bacterial load ?105 colony?forming units (CFU)/mL were positively associated with high TCCs. Viruses and bacterial load ?104 CFU/mL were positively associated with neutrophilia; negative associations were seen for Indigenous status and macrolides. In children who had not received macrolide antibiotics, bacterial load was positively associated in multivariable analyses with high TCCs at ?104 CFU/mL and with neutrophilia at ?105 CFU/mL; GMs of TCCs and neutrophil counts were significantly elevated at 104 and 105 CFU/mL compared to negative cultures. Conclusions: Our findings support a BAL threshold ?104 CFU/mL to define lower airway infection in children with chronic endobronchial disorders. äDefining lower airway bacterial infection in children with chronic end(epmc).pdf DeepDyve Pubget Overpricing