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2020 ; 31
(2
): 137-145
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gab.com Text
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English Wikipedia
Coronavirus as silent killer: recent advancement to pathogenesis, therapeutic
strategy and future perspectives
#MMPMID32313824
Raj K
; Rohit
; Ghosh A
; Singh S
Virusdisease
2020[Jun]; 31
(2
): 137-145
PMID32313824
show ga
The present outbreak associated with corona virus [CoVs] in China which is
believed to be one of the massive eruptions towards mankind in 2019-2020. In the
present scenario CoVs has been transmitted to the European and American regions
through the travellers from wide spread countries like China and Japan. The viral
disease is spreading through the contact in any form by the infected persons or
patients and creating huge risk of mortality. CoVs are a single positive-sense
RNA virus; mutation rates are higher than DNA viruses and indicate a more
effective survival adaption mechanism. Human CoVs can cause common cold and
influenza-like illness and a variety of severe acute respiratory disease such as
pneumonia. Early in infection, CoVs infects epithelial cells, macrophages,
T-cells, dendritic cells and also can affect the development and implantation of
pro-inflammatory cytokines and chemokines. It mainly produces the melanoma
differentiation associated with protein-5, retinoic acid inducible gene-1 and
endosomal toll-like receptor 3. How CoVs affects the function of the immune
system is still unclear due to lack of this knowledge. No Food and Drug
Administration approved treatment is available till date. In this review, we are
tried to explore the epidemiology, pathogenesis and current treatment of CoVs
infection. The promising therapeutics molecules against CoVs and future
prospective have been also discussed which will be helpful for researchers to
find out the new molecules for the treatment of CoVs disease.