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10.1002/jmv.24571 http://scihub22266oqcxt.onion/10.1002/jmv.24571 C7167157!7167157!27155198     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2017 ; 89 (4): 571-81 Nephropedia Template TP {{tp|p=27155198|t=2017. Antiviral activity of Carbenoxolone disodium against dengue virus infection |pdf=|usr=}}{{27155198}} gab.com Text Antiviral activity of Carbenoxolone disodium against dengue virus infection JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=27155198 #FOAvip As one of the most important mosquito?borne viral diseases, dengue infection is now becoming a global concern due to its rapid spread and rise in incidence. Currently, there is no approved vaccine or effective antiviral drug for dengue virus (DENV) infection. Glycyrrhetinic acid (GNa) and its related derivatives have been reported to inhibit a broad spectrum of viruses. However, it is unknown whether Carbenoxolone disodium (CBX), one of the GNa derivatives, affects DENV infection. Here, we found that the production of infectious DENV particles was significantly decreased by CBX treatment in DENV?permissive cells, while the viral RNA and viral protein synthesis were not affected. Moreover, results from time?of?addition study showed that the inhibitory effect of CBX on DENV was exhibited by targeting the virus itself, not the host cells. Directly incubating DENV with CBX resulted in a remarkable reduction of virus titer and virus infectivity. Furthermore, DENV RNA from progeny virions in the supernatants was significantly decreased by CBX treatment in a dose?dependent manner. Taken together, these data indicate that the antiviral activity of CBX against DENV may be mainly due to a virucidal effect exerted by the compound itself. Our work, for the first time, demonstrates that CBX has antiviral activity against DENV infection, providing useful information for development of potential therapeutic interventions against dengue. J. Med. Virol. 89:571?581, 2017. © 2016 Wiley Periodicals, Inc. Twit Text FOAVip Antiviral activity of Carbenoxolone disodium against dengue virus infection ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=27155198 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27155198 #FOAvip English Wikipedia <ref>{{Cite pmid|27155198}}</ref> Antiviral activity of Carbenoxolone disodium against dengue virus infection #MMPMID27155198 Pu J; He L; Xie H; Wu S; Li Y; Zhang P; Yang Z; Huang X J Med Virol 2017[Apr]; 89 (4): 571-81 PMID27155198show ga As one of the most important mosquito?borne viral diseases, dengue infection is now becoming a global concern due to its rapid spread and rise in incidence. Currently, there is no approved vaccine or effective antiviral drug for dengue virus (DENV) infection. Glycyrrhetinic acid (GNa) and its related derivatives have been reported to inhibit a broad spectrum of viruses. However, it is unknown whether Carbenoxolone disodium (CBX), one of the GNa derivatives, affects DENV infection. Here, we found that the production of infectious DENV particles was significantly decreased by CBX treatment in DENV?permissive cells, while the viral RNA and viral protein synthesis were not affected. Moreover, results from time?of?addition study showed that the inhibitory effect of CBX on DENV was exhibited by targeting the virus itself, not the host cells. Directly incubating DENV with CBX resulted in a remarkable reduction of virus titer and virus infectivity. Furthermore, DENV RNA from progeny virions in the supernatants was significantly decreased by CBX treatment in a dose?dependent manner. Taken together, these data indicate that the antiviral activity of CBX against DENV may be mainly due to a virucidal effect exerted by the compound itself. Our work, for the first time, demonstrates that CBX has antiviral activity against DENV infection, providing useful information for development of potential therapeutic interventions against dengue. J. Med. Virol. 89:571?581, 2017. © 2016 Wiley Periodicals, Inc. äAntiviral activity of Carbenoxolone disodium against dengue virus infe(epmc).pdf DeepDyve Pubget Overpricing