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10.1007/s11033-020-05427-1 http://scihub22266oqcxt.onion/10.1007/s11033-020-05427-1 C7165076!7165076 !32303958     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 312.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 312.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 312.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 312.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 312.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 312.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 312.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 312.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32303958 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Biol+Rep 2020 ; 47 (6 ): 4631-4650 Nephropedia Template TP {{tp|p=32303958 |t=2020. ? adrenergic receptor modulated signaling in glioma models: promoting ? adrenergic receptor-? arrestin scaffold-mediated activation of extracellular-regulated kinase 1/2 may prove to be a panacea in the treatment of intracranial and spinal malignancy and extra-neuraxial carcinoma |pdf=|usr=}}{{32303958 }} gab.com Text adrenergic receptor modulated signaling in glioma models: promoting adrenergic receptor- arrestin scaffold-mediated activation of extracellular-regulated kinase 1/2 may prove to be a panacea in the treatment of intracranial and spinal malignancy and extra-neuraxial carcinoma JO: Mol Biol Rep http://www.kidney.de/pget.php?&tw=1&pmid=32303958 #FOAvip Neoplastically transformed astrocytes express functionally active cell surface ? adrenergic receptors (?ARs). Treatment of glioma models in vitro and in vivo with ? adrenergic agonists variably amplifies or attenuates cellular proliferation. In the majority of in vivo models, ? adrenergic agonists generally reduce cellular proliferation. However, treatment with ? adrenergic agonists consistently reduces tumor cell invasive potential, angiogenesis, and metastasis. ? adrenergic agonists induced decreases of invasive potential are chiefly mediated through reductions in the expression of matrix metalloproteinases types 2 and 9. Treatment with ? adrenergic agonists also clearly reduce tumoral neoangiogenesis, which may represent a putatively useful mechanism to adjuvantly amplify the effects of bevacizumab. Bevacizumab is a monoclonal antibody targeting the vascular endothelial growth factor receptor. We may accordingly designate ?agonists to represent an enhancer of bevacizumab. The antiangiogenic effects of ? adrenergic agonists may thus effectively render an otherwise borderline effective therapy to generate significant enhancement in clinical outcomes. ? adrenergic agonists upregulate expression of the major histocompatibility class II DR alpha gene, effectively potentiating the immunogenicity of tumor cells to tumor surveillance mechanisms. Authors have also demonstrated crossmodal modulation of signaling events downstream from the ? adrenergic cell surface receptor and microtubular polymerization and depolymerization. Complex effects and desensitization mechanisms of the ? adrenergic signaling may putatively represent promising therapeutic targets. Constant stimulation of the ? adrenergic receptor induces its phosphorylation by ? adrenergic receptor kinase (?ARK), rendering it a suitable substrate for alternate binding by ? arrestins 1 or 2. The binding of a ? arrestin to ?ARK phosphorylated ?AR promotes receptor mediated internalization and downregulation of cell surface receptor and contemporaneously generates a cell surface scaffold at the ?AR. The scaffold mediated activation of extracellular regulated kinase 1/2, compared with protein kinase A mediated activation, preferentially favors cytosolic retention of ERK1/2 and blunting of nuclear translocation and ensuant pro-transcriptional activity. Thus, ?AR desensitization and consequent scaffold assembly effectively retains the cytosolic homeostatic functions of ERK1/2 while inhibiting its pro-proliferative effects. We suggest these mechanisms specifically will prove quite promising in developing primary and adjuvant therapies mitigating glioma growth, angiogenesis, invasive potential, and angiogenesis. We suggest generating compounds and targeted mutations of the ? adrenergic receptor favoring ? arrestin binding and scaffold facilitated activation of ERK1/2 may hold potential promise and therapeutic benefit in adjuvantly treating most or all cancers. We hope our discussion will generate fruitful research endeavors seeking to exploit these mechanisms. Twit Text FOAVip adrenergic receptor modulated signaling in glioma models: promoting adrenergic receptor- arrestin scaffold-mediated activation of extracellular-regulated kinase 1/2 may prove to be a panacea in the treatment of intracranial and spinal malignancy and extra-neuraxial carcinoma ????Mol Biol Rep http://www.kidney.de/pget.php?&tw=1&pmid=32303958 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32303958 #FOAvip English Wikipedia <ref>{{Cite pmid|32303958 }}</ref> ? adrenergic receptor modulated signaling in glioma models: promoting ? adrenergic receptor-? arrestin scaffold-mediated activation of extracellular-regulated kinase 1/2 may prove to be a panacea in the treatment of intracranial and spinal malignancy and extra-neuraxial carcinoma #MMPMID32303958 Ghali GZ ; Ghali MGZ Mol Biol Rep 2020[Jun]; 47 (6 ): 4631-4650 PMID32303958 show ga Neoplastically transformed astrocytes express functionally active cell surface ? adrenergic receptors (?ARs). Treatment of glioma models in vitro and in vivo with ? adrenergic agonists variably amplifies or attenuates cellular proliferation. In the majority of in vivo models, ? adrenergic agonists generally reduce cellular proliferation. However, treatment with ? adrenergic agonists consistently reduces tumor cell invasive potential, angiogenesis, and metastasis. ? adrenergic agonists induced decreases of invasive potential are chiefly mediated through reductions in the expression of matrix metalloproteinases types 2 and 9. Treatment with ? adrenergic agonists also clearly reduce tumoral neoangiogenesis, which may represent a putatively useful mechanism to adjuvantly amplify the effects of bevacizumab. Bevacizumab is a monoclonal antibody targeting the vascular endothelial growth factor receptor. We may accordingly designate ?agonists to represent an enhancer of bevacizumab. The antiangiogenic effects of ? adrenergic agonists may thus effectively render an otherwise borderline effective therapy to generate significant enhancement in clinical outcomes. ? adrenergic agonists upregulate expression of the major histocompatibility class II DR alpha gene, effectively potentiating the immunogenicity of tumor cells to tumor surveillance mechanisms. Authors have also demonstrated crossmodal modulation of signaling events downstream from the ? adrenergic cell surface receptor and microtubular polymerization and depolymerization. Complex effects and desensitization mechanisms of the ? adrenergic signaling may putatively represent promising therapeutic targets. Constant stimulation of the ? adrenergic receptor induces its phosphorylation by ? adrenergic receptor kinase (?ARK), rendering it a suitable substrate for alternate binding by ? arrestins 1 or 2. The binding of a ? arrestin to ?ARK phosphorylated ?AR promotes receptor mediated internalization and downregulation of cell surface receptor and contemporaneously generates a cell surface scaffold at the ?AR. The scaffold mediated activation of extracellular regulated kinase 1/2, compared with protein kinase A mediated activation, preferentially favors cytosolic retention of ERK1/2 and blunting of nuclear translocation and ensuant pro-transcriptional activity. Thus, ?AR desensitization and consequent scaffold assembly effectively retains the cytosolic homeostatic functions of ERK1/2 while inhibiting its pro-proliferative effects. We suggest these mechanisms specifically will prove quite promising in developing primary and adjuvant therapies mitigating glioma growth, angiogenesis, invasive potential, and angiogenesis. We suggest generating compounds and targeted mutations of the ? adrenergic receptor favoring ? arrestin binding and scaffold facilitated activation of ERK1/2 may hold potential promise and therapeutic benefit in adjuvantly treating most or all cancers. We hope our discussion will generate fruitful research endeavors seeking to exploit these mechanisms. |Adrenergic beta-Agonists/metabolism [MESH] |Animals [MESH] |Carcinoma/genetics/metabolism [MESH] |Cell Proliferation [MESH] |Glioma/genetics/*metabolism [MESH] |Humans [MESH] |MAP Kinase Signaling System/physiology [MESH] |Mitogen-Activated Protein Kinase 3/metabolism [MESH] |Phosphorylation [MESH] |Protein Transport [MESH] |Receptors, Adrenergic, beta-2/genetics [MESH] |Receptors, Adrenergic, beta/*metabolism [MESH] |Signal Transduction/drug effects [MESH] |Spinal Neoplasms/genetics/metabolism [MESH] |Vascular Endothelial Growth Factor A/metabolism [MESH] |beta-Adrenergic Receptor Kinases/metabolism [MESH]? adrenergic receptor modulated signaling in glioma models: promoting (epmc).pdf DeepDyve Pubget Overpricing