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Omics?Based Systems Vaccinology for Vaccine Target Identification #MMPMIDC7163697
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Drug Dev Res 2012[Dec]; 73 (8): 559-68 PMIDC7163697show ga
Preclinical ResearchCopyright 2011 Wiley-Liss, Inc., A Wiley CompanyThis article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.Omics technologies include genomics, transcriptomics, proteomics, metabolomics, and immunomics. These technologies have been used in vaccine research, which can be summarized using the term ?vaccinomics.? These omics technologies combined with advanced bioinformatics analysis form the core of ?systems vaccinology.? Omics technologies provide powerful methods in vaccine target identification. The genomics?based reverse vaccinology starts with predicting vaccine protein candidates through in silico bioinformatics analysis of genome sequences. The VIOLIN Vaxign vaccine design program (http://www.violinet.org/vaxign) is the first web?based vaccine target prediction software based on the reverse vaccinology strategy. Systematic transcriptomics and proteomics analyses facilitate rational vaccine target identification by detesting genome?wide gene expression profiles. Immunomics is the study of the set of antigens recognized by host immune systems and has also been used for efficient vaccine target prediction. With the large amount of omics data available, it is necessary to integrate various vaccine data using ontologies, including the Gene Ontology (GO) and Vaccine Ontology (VO), for more efficient vaccine target prediction and assessment. All these omics technologies combined with advanced bioinformatics analysis methods for a systems biology?based vaccine target prediction strategy. This article reviews the various omics technologies and how they can be used in vaccine target identification.