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Infectomics Screening for Novel Antiviral Drug Targets
#MMPMIDC7163650
Liu Y
; Yin Q
; Yuan Y
; Yang W
; Jiang C
; Huang C
Drug Dev Res
2012[Nov]; 73
(7
): 365-80
PMIDC7163650
show ga
[Table: see text] Infectomics, a novel way to globally and comprehensively
understand the interactions between microbial pathogens and their hosts, has
significantly expanded understanding of the microbial infections. The infectomics
view of viral?host interactions on the viral perspective principally focuses on
gene acquisition, deletion, and point mutation, while traditional antiviral drug
discovery concentrates on viral encoding proteins. Recently, high?throughput
technologies, such as mass spectrometry?based proteomics, activity?based protein
profiling, microarray analysis, yeast two?hybrid assay, small interfering RNA
screening, and micro RNA profiling, have been gradually employed in the research
of virus?host interactions. Besides, signaling pathways and cellular processes
involved in viral?host interactions provide new insights of infectomics in
antiviral drug discovery. In this review, we summarize related infectomics
approaches in the studies of virus?host interactions, which shed light on the
development of novel antiviral drug targets screening.
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