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10.1016/j.jcyt.2020.04.089

http://scihub22266oqcxt.onion/10.1016/j.jcyt.2020.04.089
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C7163352!7163352!32933835
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suck abstract from ncbi


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pmid32933835      Cytotherapy 2020 ; 22 (11): 602-5
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  • Cell-based therapies for coronavirus disease 2019: proper clinical investigations are essential #MMPMID32933835
  • Khoury M; Rocco PR; Phinney DG; Krampera M; Martin I; Viswanathan S; Nolta JA; LeBlanc K; Galipeau J; Weiss DJ
  • Cytotherapy 2020[Nov]; 22 (11): 602-5 PMID32933835show ga
  • The serious consequences of the global coronavirus disease 2019 (COVID-19) pandemic have prompted a rapid global response to develop effective therapies that can lessen disease severity in infected patients. Cell-based approaches, primarily using mesenchymal stromal cells (MSCs), have demonstrated a strong safety profile and possible efficacy in patients with acute respiratory distress syndrome (ARDS), but whether these therapies are effective for treating respiratory virus-induced ARDS is unknown. According to the World Health Organization International Clinical Trials Registry Platform and the National Institutes of Health ClinicalTrials.gov databases, 27 clinical investigations of MSC-based cell therapy approaches have begun in China since the onset of the COVID-19 outbreak, with a growing number of academic and industry trials elsewhere as well. Several recent published reports have suggested potential efficacy; however, the available data presented are either anecdotal or from incomplete, poorly controlled investigations. Therefore, although there may be a potential role for MSCs and other cell-based therapies in treatment of COVID-19, these need to be investigated in a rationally designed, controlled approach if safety and efficacy are to be demonstrated accurately. The authors urge that the field proceed by finding a balance between swift experimentation and communication of results and scientifically coherent generation and analysis of clinical data.
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