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2020 ; 2
(3
): 100061
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Therapeutic management of patients with COVID-19: a systematic review
#MMPMID34316558
Tobaiqy M
; Qashqary M
; Al-Dahery S
; Mujallad A
; Hershan AA
; Kamal MA
; Helmi N
Infect Prev Pract
2020[Sep]; 2
(3
): 100061
PMID34316558
show ga
BACKGROUND: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the
causative agent of coronavirus disease 2019 (COVID-19), which was declared a
global pandemic by the World Health Organization on 11(th) March 2020. The
treatment guidelines for COVID-19 vary between countries, yet there is no
approved treatment to date. AIM: To report any evidence of therapeutics used for
the management of patients with COVID-19 in clinical practice since emergence of
the virus. METHODS: A systematic review protocol was developed based on the
PRISMA statement. Articles for review were selected from Embase, Medline and
Google Scholar. Readily accessible peer-reviewed, full articles in English
published from 1(st) December 2019 to 26(th) March 2020 were included. The search
terms included combinations of: COVID, SARS-COV-2, glucocorticoids, convalescent
plasma, antiviral and antibacterial. There were no restrictions on the types of
study eligible for inclusion. RESULTS: Four hundred and forty-nine articles were
identified in the literature search; of these, 41 studies were included in this
review. These were clinical trials (N=3), case reports (N=7), case series (N=10),
and retrospective (N=11) and prospective (N=10) observational studies. Thirty-six
studies were conducted in China (88%). Corticosteroid treatment was reported most
frequently (N=25), followed by lopinavir (N=21) and oseltamivir (N=16).
CONCLUSIONS: This is the first systematic review to date related to medication
used to treat patients with COVID-19. Only 41 studies were eligible for
inclusion, most of which were conducted in China. Corticosteroid treatment was
reported most frequently in the literature.